Sartorius eBook - 11

THE FUTURE OF DRUG DISCOVERY: LIVE 3D CELL ANALYSIS

Matthias Lutolf, EPFL

An illustration of an iPSC colony emerging in a three-dimensional gel made with DEMCON Nymus3D.

adjusting the composition-and hence the

physical and chemical factors that offer the most

stiffness and density-of the surrounding gel. As

efficient transformation," said Dr. Lutolf. "Once

a result, the gel exerts different forces on the cells,

you find it, it is a matter of resources and time to

"squeezing" them.

create stem cells on a larger scale."

As a new phenomenon, this is not entirely

Possiby the greater achievement of this

understood. However, the scientists propose that

discovery is quantity. The technique can be

the three-dimensional environment is key to this

applied to a large number of cells to produce

process, generating mechanical signals that work

stem cells on an industrial scale. Dr. Lutolf's lab is

together with genetic factors to make the cell

looking into this, but their main focus is to better

easier to transform into a stem cell.

understand the phenomenon, and to find the

"Each cell type may have a 'sweet spot' of

"sweet spots" for other cell types.

GENengnews.com

| 11



http://www.GENengnews.com

Sartorius eBook

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