Sartorius eBook - 12
THE FUTURE OF DRUG DISCOVERY: LIVE 3D CELL ANALYSIS
The researchers used a technique called confocal microscopy to confirm that the cell lines were forming spheres.
Cancer Screen with Spheroids
Shows Promise Therapeutically
S
cientists from The Scripps Research
identified one potential drug for a cancer
Institute say they have developed a new
gene and reported its results ("A Novel Three-
method to screen for potential cancer
Dimensional High-Throughput Screening
drugs. The technique makes use of tiny, three-
Approach Identifies Inducers of a Mutant KRAS
dimensional, ball-like aggregates of cells called
Selective Lethal Phenotype") in Oncogene.
spheroids, which can be used to interrogate
"The RAS proteins are the most frequently
hundreds or even thousands of compounds
mutated oncogenes in cancer, with the highest
rapidly using high-throughput screening (HTS).
frequency found in pancreatic, lung, and colon
Using this approach, the team has already
tumors. Moreover, the activity of RAS is required
12 |
GENengnews.com
https://www.nature.com/articles/s41388-018-0257-5
https://www.nature.com/articles/s41388-018-0257-5
https://www.nature.com/articles/s41388-018-0257-5
https://www.nature.com/articles/s41388-018-0257-5
http://www.GENengnews.com
Sartorius eBook
Table of Contents for the Digital Edition of Sartorius eBook
Contents
Sartorius eBook - 1
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Sartorius eBook - Contents
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