Sartorius eBook - 15

THE FUTURE OF DRUG DISCOVERY: LIVE 3D CELL ANALYSIS

Immunotherapy Screening Using
Immune-Enhanced Organoids

T

umor organoids are becoming
commonplace for drug discovery efforts
and are helping researchers develop

targeted therapies for aggressive cancer types.
Yet now, investigators at the Wake Forest Institute
for Regenerative Medicine (WFIRM) are looking
to develop a patient-specific tumor organoid
platform to improve immunotherapy treatment
selection for patients in need.
"Immunotherapy drugs are not inexpensive,
and it is not uncommon for the cost of therapy
Cincinnati Children's

to be measured in millions of dollars per patient,"
explained senior study author Aleks Skardal,
PhD, who was an assistant professor at WFIRM
at the time of the study. "This bioengineered
patient-specific tumor model opens the door to

This confocal microscopic image shows a tiny bioengineered
human liver organoid grown in the lab with pluripotent stem
cells.

speedier drug screening to get the best therapy
to patients as soon as possible and rationalize the

able to combine melanoma cells and white

use of immunotherapy drugs to the patients that

blood cells from the patients' peripheral blood

will show a clinical response."

and lymph nodes and create patient-specific,

Findings from the new study, "Model of
Patient-Specific Immune-Enhanced Organoids
for Immunotherapy Screening: Feasibility Study,"

immune-active tumor organoids to test their
response to immunotherapy treatment.
Interestingly, for many cancers, the immune

were published recently in the Annals of Surgical

response is only possible after appropriate

Oncology. For this study, the researchers were

exposure of the specific immune cells, T cells, to

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https://link.springer.com/article/10.1245%2Fs10434-019-08143-8 https://link.springer.com/article/10.1245%2Fs10434-019-08143-8 https://link.springer.com/article/10.1245%2Fs10434-019-08143-8 http://www.GENengnews.com

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