Sartorius eBook - 16
THE FUTURE OF DRUG DISCOVERY: LIVE 3D CELL ANALYSIS
tumor antigens. However, tumor cells develop
recognize and kill their own tumor without the use
mechanisms to evade the immune system and
of drugs. Creating such a clinically relevant model
go unnoticed. Immunotherapy allows these T
has the potential to revolutionize the way we
cells to re-detect tumor cells and eventually kill
approach both cancer research and cancer care."
them.
Organoids are tiny, 3D tissue-like structures
created in the laboratory that mimic the function
of human tissues and organs such as the heart,
liver, lung, blood vessels, as well as cancer. The
organoids are used as a testing and predicting
National Institute of Allergy and Infectious Diseases, NIH
platform to model diseases, evaluate the efficacy
and/or toxicity of new and existing drugs, and
can also be used to test environmental hazards.
To construct the platforms, tumor cells and
lymph node biospecimens were surgically
obtained from eight patients with stage III and
IV melanoma and co-cultured to create the
Brightfield microscope image of an organoid during
development, showing highly structured regions forming.
"These constructs will potentially allow us
organoids. From the biospecimens received, an
average of 75 to 100 organoids were created
in each instance and were typically split into
to predict immunotherapy effectiveness and
equal numbers of patient tumor organoids and
generate adaptive immunity at the level of the
immune-enhanced patient tumor organoids.
individual patient," noted lead study investigator
Immunotherapy testing was initiated on day
Konstantinos Votanopoulos, MD, PhD, associate
7 and the organoids were incubated under
professor of surgical oncology at the Wake Forest
these conditions for 72 hours. This allowed the
Comprehensive Cancer Center (WFCCC) and
researchers to demonstrate that immunotherapy
co-director of the Wake Forest Organoid Research
treatment was effective in killing of the tumor
Center (WFORCE). "Our team has previously
only in the immune-enhanced patient tumor
co-cultured lymph nodes and tumor from the
organoids, where the organoids without immune
same patient for screening purposes, but this is
cells experienced no tumor death.
the first time we have used this platform to train
the immune system of the patient to directly
16 |
GENengnews.com
"Ten biospecimen sets obtained from
eight stage III and IV melanoma patients
http://www.GENengnews.com
Sartorius eBook
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