Sartorius eBook - 17

THE FUTURE OF DRUG DISCOVERY: LIVE 3D CELL ANALYSIS

were reconstructed as symbiotic immune/

system within 24 hours of obtaining the tissue

tumor organoids between September 2017

specimen. It allows us to track the evolution of

and June 2018," the authors wrote. "Successful

disease within the patient and potentially adjust

establishment of viable organoid sets was 90%

the treatment based on the way the cancer

(9/10), although organoid yield varied with

changes over time."

biospecimen size. Average time from organoid

The organoid platforms are a disruptive

development to initiation of immunotherapy

technology that could potentially save lives

testing was 7 days. In three patients for whom

while also saving billions of dollars of taxpayer

a node was not available, it was substituted

money and effect policy design. In 2017, the

with peripheral blood mononuclear cells. iPTO

cost of health care in the United States reached

response to immunotherapy was similar to

$3.5 trillion and is projected by the Centers for

specimen clinical response in 85% (6/7) patients."

Medicare & Medicaid Services to reach $6 trillion

The technique for growing organoids

by 2027. A portion of this cost is allocated in

has rapidly improved since the early 2010s

treating side effects from drugs that quite often

and WFIRM has been at the forefront of this

have no meaningful activity for the patient.

technology.

"Development of 3D mixed immune-

"WFIRM scientists have successfully created

enhanced tumor/node organoids is a feasible

organoids replicating most of the main organs of

platform, allowing individual patient immune

the body such as the liver, heart, brain, and lung

system and tumor cells to remain viable for

to screen drugs and model diseases, which can

studying of personalized immunotherapy

eliminate the need for animal testing," remarked

response," the authors concluded.

Shay Soker, PhD, a professor of regenerative
medicine who leads the organoid biofabrication
core at WFIRM and who was not part of the
current study. "This method generates a 100%
human experimental platform that recreates the

ADDITIONAL CONTENT
Web article: Accelerate your organoid
discovery with an established protocol
and integrated analysis, enabling
reproducible culture techniques for
downstream assay preparation.

interaction between host, tumor, and immune

GENengnews.com

| 17


https://www.essenbioscience.com/en/applications/cell-monitoring-workflows/organoid-qc/ https://www.essenbioscience.com/en/applications/cell-monitoring-workflows/organoid-qc/ http://www.GENengnews.com

Sartorius eBook

Table of Contents for the Digital Edition of Sartorius eBook

Contents
Sartorius eBook - 1
Sartorius eBook - 2
Sartorius eBook - 3
Sartorius eBook - Contents
Sartorius eBook - 5
Sartorius eBook - 6
Sartorius eBook - 7
Sartorius eBook - 8
Sartorius eBook - 9
Sartorius eBook - 10
Sartorius eBook - 11
Sartorius eBook - 12
Sartorius eBook - 13
Sartorius eBook - 14
Sartorius eBook - 15
Sartorius eBook - 16
Sartorius eBook - 17
Sartorius eBook - 18
Sartorius eBook - 19
Sartorius eBook - 20
Sartorius eBook - 21
Sartorius eBook - 22
Sartorius eBook - 23
Sartorius eBook - 24
Sartorius eBook - 25
Sartorius eBook - 26
Sartorius eBook - 27
Sartorius eBook - 28
Sartorius eBook - 29
Sartorius eBook - 30
Sartorius eBook - 31
Sartorius eBook - 32
Sartorius eBook - 33
Sartorius eBook - 34
Sartorius eBook - 35
Sartorius eBook - 36
Sartorius eBook - 37
Sartorius eBook - 38
Sartorius eBook - 39
Sartorius eBook - 40
Sartorius eBook - 41
Sartorius eBook - 42
Sartorius eBook - 43
Sartorius eBook - 44
Sartorius eBook - 45
Sartorius eBook - 46
https://www.nxtbookmedia.com