Sartorius eBook - 18
THE FUTURE OF DRUG DISCOVERY: LIVE 3D CELL ANALYSIS
SARS-CoV-2 Infection of
Gut Organoids Bolsters Case
for Intestinal Transmission
G
ut organoids, three-dimensional
for SARS-CoV-2 transmission. That is, SARS-CoV-2
cell culture models of the intestine,
transmission via gastrointestinal organs, as well as
have been used to demonstrate that
that via the respiratory organs, may account for
the coronavirus SARS-CoV-2 can infect cells of
the intestine and multiply there. The models
the devastating spread of COVID-19.
Patients with COVID-19 show a variety of
indicate that SARS-CoV-2 might also infect and
symptoms associated with respiratory organs-
replicate in the cells lining the human intestine. It
such as coughing, sneezing, shortness of breath,
is even possible that the human intestine is-as
and fever-and the disease is transmitted via
researchers have suspected-a significant route
tiny droplets that are spread mainly through
Electron micrograph of SARS-CoV-2 virus particles,
isolated from a patient.
coughing and sneezing. One-third of the patients,
however, also have gastrointestinal symptoms,
such as nausea and diarrhea. In addition, the
virus can be detected in human stool long after
the respiratory symptoms have been resolved.
This suggests that the virus can also spread via
National Institute of Allergy and Infectious Diseases, NIH
so-called fecal-oral transmission.
Though the respiratory and gastrointestinal
organs may seem very different, there are some
key similarities. A particularly interesting similarity
is the presence of the ACE2 receptor, the receptor
through which the COVID-19 causing SARS-CoV-2
virus can enter the cells. The inside of the
18 |
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