Sartorius eBook - 21

THE FUTURE OF DRUG DISCOVERY: LIVE 3D CELL ANALYSIS

Live-Cell Monitoring: Optimizing
Workflows for Advanced Cell Models
Ensure Confidence in Your Cell Assay

Monitoring as a Key Component
of Cell Culture Workflows

L

optimization of these advanced models.
Advanced cell assays, such as those that model

everaging the recent innovations in cell

disease states and are suitable for screening

source, manipulation, and assay readout,

therapeutic agents, are often laborious to

researchers can better recapitulate the

develop, involving many stages, and may only be

in vivo environment, and so push the boundaries

ready to test after relatively long timeframes. The

of biomedical research and regenerative

culture may require patient-derived or induced

medicine. As cell-based assays become technically

pluripotent stem cells (iPSC) and may then

more complex, the need to holistically capture

undergo manipulations, such as differentiation,

dynamic and sometimes subtle cellular events

activation, or genetic modulation via techniques

becomes ever more important. By providing

such as CRISPR/Cas9. Further complexities in the

real-time imaging data of cellular events without

cellular organization may also be required, for

disturbing the sample during the cell culture

example, the use of heterogeneous cultures or

workflow, live-cell imaging can support the

the formation of 3D structures.

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Sartorius eBook

Table of Contents for the Digital Edition of Sartorius eBook

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