Sartorius eBook - 32

THE FUTURE OF DRUG DISCOVERY: LIVE 3D CELL ANALYSIS

Future Perspectives of

treatment effects. The benefits offered by these

Live Cell Imaging

advanced and interconnected cell assays can only

Advanced cell cultures have a bright future

be realized with optimal QC of each connecting

across multiple applications in basic science,

part, particularly when using complex 3D

disease modeling, and development of novel

structures and iPSCs from patient-derived sources

therapeutics. Cell cultures modeling biological

in their construction.

development and disease states have enormous

As advanced cell cultures may play a key

potential in expediting the drug discovery

role in future personalized treatments, QC must

process in the face of ever-increasing drug

ensure the safety of patients and the integrity

attrition rates.

of data. In concert with technological advances,

Organoids represent a rapidly expanding

the QC of 3D cell cultures at every stage of cell

family of in vitro 3D cell cultures that display

production will improve their quality, quantity,

realistic microanatomy of organ-specific cell types

and efficacy, thus making "cells as therapeutics" a

and can develop and self-organize similarly to

reality.

how they would in vivo17. These advanced 3D

In the race to find new therapeutic options

structures are being developed to more closely

for cancer, neurological disease, heart failure, and

recapitulate the functions of organs, to provide

other rare conditions, gene editing with CRISPR/

more clinically relevant cell assays readout from

Cas technology has become a keen contender.

absorption, distribution, metabolism, excretion,

As this application expands, the need to monitor

and toxicology (ADME-tox) drug screening assays.

cell cultures for temporal and spatial downstream

Another advanced and complex cell

off-target effects is increasingly important18.

application is 'organ-on-a-chip' technology, which

Live-cell imaging and analysis offers a practical

comprises miniature models of human organs

solution by identifying changes in cell behavior,

housed on microfluidic cell culture chips. These

allowing off-target effects and their causes to

chips can produce clinically relevant disease

be interrogated, complementing other analysis

phenotypes and pharmacological responses by

techniques.

reconstituting the microenvironmental, structural,

The development of advanced cell culture

and functional complexity of living human

assays offers promise across many sectors, but

organs. A microfluidic platform connecting cell

their success is underpinned by optimal and

culture assays from multiple organs can replicate

continual QC. The combination of automatic

a 'body-on-a-chip' for multisystem assessment of

capturing and analysis of multiparametric data

32 |

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Sartorius eBook

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