Sartorius - November 2021 - Simplifying Adeno Associated Virus - 28

10
8
6
4
2
-2
Figure 6: MVDA contribution plots comparing
process trajectory data from a batch that
produces high rAAV8 titer to average batch
from Sf9 cells cultured in Ambr®
bioreactors.
15 micro
0.25
60
Time (hr)
0.2
70
80
90
100
110
120
+3 std. dev
Average
-3 std. dev
0.15
0.1
0.05
-0.05
-0.1
-0.15
20
30
40
50
60
Time (hr)
70
80
90
100
110
120
+3 std. dev
Average
-3 std. dev
Figure 7: MVDA of air | O2 flow rate data from
Sf9 cells culture transiently producing rAAV8
in Ambr®
15 micro bioreactors.
60 28 | GENengnews.com
70
80
Time (hr)
90
100
110
120
+3 std. dev
Average
-3 std. dev
air/O2 flow rate
Score Contribution (CS2_4 - Average)
Sf9 Medium 2
Sf9 Medium 1
Ratio log (Bac-RepCap | Bac-ITR)
Cell Density (106
)
Lysis Reagent 1
Lysis Reagent 2
SM13.t1 (Evolution Trajectories)
Ratio log (Bac-RepCap | Bac-ITR) × Ratio log

Sartorius - November 2021 - Simplifying Adeno Associated Virus

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