Sartorisu-Sowmya eBook - 24

Yuan Tian, La Jolla Institute for Immunology

DECIPHERING THE IMMUNE RESPONSE TO VIRAL INFECTION

Dengue-specific CD4 cells have both a pro-inflammatory function and an antiinflammatory function, which is typically not seen in acute viral infections. Each dot is
a double-positive cell with the color of each dot representing the expression level of a
protein named TIGIT, which is an inhibitory immunoreceptor, in each cell.

24 | GENengnews.com

between patients with mild dengue fever or with severe dengue
hemorrhagic fever.
Detailed findings appeared December 24 in the journal Cell
Reports, in an article titled, "Molecular Signatures of Dengue
Virus-Specific IL-10/IFN- γ Co-producing CD4 T Cells and Their
Association with Dengue Disease."
"We identified antigen-specific IL-10+IFN- γ+ double-positive
CD4 T cells during acute dengue virus infection," wrote the
article's authors. "While the transcriptomic signatures of doublepositive cells partially overlapped with those of cytotoxic
and type 1 regulatory CD4 T cells, the majority of them were
noncytotoxic/Tr1 and included IL21, IL22, CD109, and CCR1."
When analyzing dengue-specific CD4 T cells, the researchers
realized that the responding CD4 T cells, have both a
pro-inflammatory function (regulated by the cytokine interferon
gamma, or IFN- γ) and an anti-inflammatory function (regulated
by the cytokine IL-10) which is typically not seen in acute viral
infections. To comprehensively define these dengue-virusspecific T cells in hospitalized patients, researchers used whole
transcriptome analysis to determine if there was a difference in
the quality of the increased response.
"Although we observed a higher frequency of double-positive
cells in dengue hemorrhagic fever, the transcriptomic profile of
double-positive cells was similar in dengue fever and dengue
hemorrhagic fever, suggesting that dengue hemorrhagic fever

https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31598-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124719315980%3Fshowall%3Dtrue https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31598-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124719315980%3Fshowall%3Dtrue https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31598-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124719315980%3Fshowall%3Dtrue http://www.GENengnews.com

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