Sartorisu-Sowmya eBook - 6

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DECIPHERING THE IMMUNE RESPONSE TO VIRAL INFECTION

co-author of the researchers report, which is published in Nature
Medicine.
"We showed that even though COVID-19 is caused by a
new virus, in an otherwise healthy person, a robust immune
response across different cell types was associated with clinical
recovery, similar to what we see in influenza," added University
of Melbourne Professor Katherine Kedzierska, PhD, a laboratory
head at the Doherty Institute. Nguyen said the report is the
first to describe broad immune responses to COVID-19. The
researchers's findings are reported in a paper titled, "Breadth of
concomitant immune responses prior to patient recovery: a case
report of non-severe COVID-19."
6 | GENengnews.com

The patient was an otherwise healthy, non-smoking woman,
aged 47 years, from Wuhan, Hubei province, in China, who had
travelled to Australia 11 days previously, and presented to an
emergency department in Melbourne, Australia. Her symptoms,
which had started four days before she went to hospital,
included lethargy, sore throat, dry cough, pleuritic chest pain,
mild dyspnea and subjective fevers.
"Three days after the patient was admitted, we saw large
populations of several immune cells, which are often a tell-tale
sign of recovery during seasonal influenza infection, so we
predicted that the patient would recover in three days, which
is what happened," Nguyen said. The SARS-CoV-2 virus was
detected in nasopharyngeal, sputum and fecal samples from
the patient on presentation at the hospital on day four, and
again on days 5-6, but was undetectable from day 7. She was
discharged to home isolation on day 11. Her symptoms resolved
completely by day 13, and she remained well at day 20, "with
progressive increases in plasma SARS-CoV-2-binding IgM and
IgG antibodies from day 7 until day 20."
"We have provided evidence on the recruitment of immune
cell populations (ASCs, TFH cells and activated CD4+ and
CD8+ T cells), together with IgM and IgG SARS-CoV-2-binding
antibodies, in the patient's blood before the resolution of
symptoms," the authors wrote. "Collectively, our study provides
novel contributions to the understanding of the breadth and
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