TTP Labtech, Phenotypic Screening - 12

Cellular Models
for Finer Screening
Neil McKenna, Ph.D.

The cost of bringing a new drug to the market
has recently been estimated by Forbes Magazine
at $5 billion. This figure derives in large part
from high attrition rates in the drug development pipeline that arise from failures in drug
efficacy or adverse toxic events, such that in
excess of 90% of all small molecules that enter
Phase I testing are ultimately not approved.
Accordingly, significant effort is being invested
in developing new in vitro models that more
accurately recapitulate the effect of small molecule
drug candidates on cellular pathways and
12 | GENengnews.com

processes in vivo.
At "Physiologically Relevant Cellular Models
for Drug Discovery," a CHI conference held
recently in La Jolla, CA, several speakers described
advances in the characterization of cell-based
platforms for drug screening, and in the use of
pathway analysis to model the effect of drug
candidates on critical cellular processes.
While convenient, traditional two-dimensional
(2D) monolayer cell culture techniques fail to fully
recapitulate the mechanical and chemical gradients
to which cells are exposed in the body, and which

Additional Content

VIDEO:
3D Cell Culture Models
Why they have become so
relevant to screening
View it now!

t

Developers Are Looking at 3D Systems to Clarify how
Cellular Pathways Respond to Small Molecule Candidates


http://discover.ttplabtech.com/GEN-eBook_3D-assays.html http://www.GENengnews.com

TTP Labtech, Phenotypic Screening

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TTP Labtech, Phenotypic Screening - 1
TTP Labtech, Phenotypic Screening - 2
TTP Labtech, Phenotypic Screening - 3
TTP Labtech, Phenotypic Screening - Contents
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