TTP Labtech, Phenotypic Screening - 16

PHENOTYPIC SCREENING an e-Book Series Cellular Models for Finer Screening

polysaccharides and proteins.
"Suspension of the cells in the matrix allows
them to establish cell-cell interactions that closely
mimic the 3D environment within the body,
providing a more realistic pathway infrastructure
for drug candidate screening for efficacy, selectivity,
and toxicity," Dr. Dordick explained. Cell populations in specific wells of the TEAMChip can be
individually transfected with the desired amount
of specific gene(s), in effect programming them to
express different levels and combinations of
molecules that critically impact the response of
a cell to a specific compound, such as drug
metabolism enzymes, and components of
cellular signaling pathways.

16 | GENengnews.com

"Rapidly identifying the potency, selectivity, and
toxicity is a major goal in drug screening," remarked
Dr. Dordick. "Our initial focus with TEAMChip is
dialing in the expression levels of enzymes in drug
metabolism pathways such as CYP450 and UDPglucuronyltransferases, which will permit the influence
of human metabolism on drug candidate toxicity to
be predicted on a more personalized basis."
Dr. Dordick also highlighted the TEAMChip
platform's potential for transfecting genes within a
specific signaling pathway to modulate flux within
that pathway. "When drug candidates are screened
in such TEAMChips, it is possible to study the
interaction of the compound with the relevant
signaling pathway," he concluded. n


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TTP Labtech, Phenotypic Screening

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