TTP Labtech, Phenotypic Screening - 19

PHENOTYPIC SCREENING an e-Book Series The Renaissance of Phenotypic Research

for targets that could not be examined without living
cells in the wells. The number of targets of interest
for the pharmaceutical companies was drastically
increased with the human genome project, leading
to an increase in screening activities.
Phenotypic Screening
Gives the Big Picture
High-content screening (as in automated
microscopy with automated image analysis) was
initially developed in the late 1990s for screening
those targets that were difficult to come by with
more traditional detection methods. However,
while it enabled certain target-based screens, it
directly provided additional insights beyond the
simple quantified effect, such as toxicity or
unexpected changes of cellular phenotype. While
classical screens with a single readout only allow
you to quantify the measured effect, high-content
screens promise more: Additional phenotypic
changes can be observed and also quantified,
allowing in principle a distinction of the chemical
responses into three classes: similar to untreated
19 | GENengnews.com

High-content screening, uniquely capable of managing high throughput, is the workhorse technology for both
phenotypic- and target-based screening in the drug discovery process. Genedata


http://www.GENengnews.com

TTP Labtech, Phenotypic Screening

Table of Contents for the Digital Edition of TTP Labtech, Phenotypic Screening

Contents
TTP Labtech, Phenotypic Screening - 1
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