TTP Labtech, Phenotypic Screening - 21

Novel 3D

Cell Culture Systems
Vicki Glaser

To predict drug response or toxicity, the
pharmaceutical industry is increasingly performing
smaller-scale validation studies of experimental
drug compounds in novel 3D cell culture models
intended to mimic more closely the structure,
activity, and extracellular environment of
tissues in vivo.
Following high-throughput, large-scale
screening assays performed in 2D systems, these
smaller, secondary screens in 3D microtissue
models are more likely to be predictive of how
21 | GENengnews.com

cells will react in vivo. Several presentations at
SMi Group's recent "Cell Culture" conference
in London focused on advances in novel 3D cell
culture systems and applications.
The things we see in 2D may not reflect
what is happening in vivo, mainly due to the
"lack of architecture in 2D systems, which
influences the biological response in many
difference phenotypes," said Olivier Pardo,
Ph.D., team leader at the Cellular Regulatory
Networks Group, Imperial College, London.

Additional Content

Download This Poster
Rapid analysis of 3D cultures in
soft agar and on ultra-low
attachment plates using a
laser scanning imaging system
AUTHORS: Anne F. Hammerstein, Ph.D.

and Paul G. Wylie, Ph.D.

Download now!

t

New Models more Closely Resemble the Structure,
Activity, and Extracellular Environment of Tissues In Vivo


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TTP Labtech, Phenotypic Screening

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