TTP Labtech, Phenotypic Screening - 27

PHENOTYPIC SCREENING an e-Book Series Novel 3D Cell Culture Systems

produced externally as 3D spherical constructs and
then loaded onto a microchip, which is composed
of interconnected compartments.
"There is consensus in the pharmaceutical
industry that 3D model systems can provide a higher
quality of information in vitro," concluded Dr. Kelm.
Nanofibers
Peptisyntha, a member of the Solvay group,
applied its expertise in peptide synthesis chemistry
to develop a family of short peptides that are able to
self-assemble and form nanofibers. These nanofibers
exist in a hydrogel capable of supporting 3D cell
cultures.
"The major benefit achieved with 3D or
pseudo-3D culture is the higher cell density that can

27 | GENengnews.com

be obtained when compared to 2D culture," said
Marc Fouassier, business development manager.
"This is an extremely important aspect for the
manufacture of certain cell lines, and certain targeted
cell applications for instance in cell therapy."
Using Peptisyntha's hydrogel system, cells grow
on a soft coating prepared from the self-assembling
peptides, which mimics the extracellular matrix. The
peptide coatings can be prepared on various plastic
surfaces traditionally used for cell culture, including
polystyrene, polyethylene terephthalate, and
polycarbonate.
According to Fouassier, advantages include the
fully synthetic, animal-free, GMP origin of these
hydrogel peptides, which are particularly useful
for culturing cells that require adhesion. n


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TTP Labtech, Phenotypic Screening

Table of Contents for the Digital Edition of TTP Labtech, Phenotypic Screening

Contents
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