Vim & Vigor - Spring 2018 - University of Virginia - 53

CURE

NOT JUST
ANYONE CAN BE A

STOOL DONOR

The nation's main supplier of the stool used in
fecal transplants, OpenBiome, turns away more
than 95 percent of potential donors for many reasons: obesity, depression or a parasite infection.
Started by Massachusetts Institute of
Technology researchers, the nonprofit now
sends stool to more than 850 medical centers
treating patients with recurrent C. diff, including UVA Health System. "It comes to us frozen," says Ann Hays, MD, who started the UVA
Complicated C. difficile Clinic along with Cirle
Warren, MD. "Initially we checked their stools
for infection before using on our patients. We
found OpenBiome has a very rigorous screening
process, doing more testing and elimination of
donors than blood donation."

TREATMENT FOR OBESITY,
DEPRESSION?

500,000
Americans contract
C. diff each year

GETTY IMAGES

UVA became one of the
FIRST IN THE NATION
to offer fecal transplants
as a cure for C. diff.

Hays expects to one day see work from fecal
transplant and intestinal microbiome researchers
contributing to new treatments for more than
C. diff, including Parkinson's disease, autism,
depression, anxiety and even obesity. She has
seen patients with inflammatory bowel disease
(IBD) improve significantly after a fecal transplant for C. diff. But, she cautions, IBD also worsens in about 20 percent of these patients after a
fecal transplant. "The results of preliminary studies using fecal transplant as a treatment for IBD
suggest that fecal transplant will likely require
repeated and donor-specific stool. It seems to
work with stool from some donors but not all,
and if done earlier in the course of the disease."

WEBSITE

Know Someone
Suffering from
C. diff?
Only a fraction of those with repeated
bouts of this gut infection have come
to the UVA Complicated C. difficile
Clinic, says Ann Hays, MD. Talk to your
doctor about a referral and learn
more at uvahealth.com/cdiff.

SPRING 2018

53



http://www.uvahealth.com/cdiff

Table of Contents for the Digital Edition of Vim & Vigor - Spring 2018 - University of Virginia

Contents
Vim & Vigor - Spring 2018 - University of Virginia - Cover1
Vim & Vigor - Spring 2018 - University of Virginia - Cover2
Vim & Vigor - Spring 2018 - University of Virginia - Contents
Vim & Vigor - Spring 2018 - University of Virginia - 2
Vim & Vigor - Spring 2018 - University of Virginia - 3
Vim & Vigor - Spring 2018 - University of Virginia - 4
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Vim & Vigor - Spring 2018 - University of Virginia - 53
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Vim & Vigor - Spring 2018 - University of Virginia - Cover3
Vim & Vigor - Spring 2018 - University of Virginia - Cover4
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