Perspectives - Winter 2016 - 20

b

a

Goblet cell

c

d

e

f

Nφ
Mφ
FoxP3+
TREG

CD4+
T cell

TNF
IFN-γ

Inflammation

P

P

NFκB

BOTTOM-LINE
The bottom-line to the probiotics story for
producers is really all about the adoption of
best practices to maintain healthy herds and
flocks. Using the best tools available should
lead to the best results. Evidence repeatedly shows that the proper use of an effective
daily-fed probiotic can provide a repeatable,
consistent return on the investment.

20

Perspectives Magazine

NFκB

IL-8

IL-8

IL-10
TGF-β

Pathogen

Probiotic

No inflammation

Dendritic
cell

Intestinal
epithelium

Figure 1: Potential mechanisms of actions of probiotic bacteria.
immune system, either to cause or prevent
inflammation.
f. Some probiotics (or their products)
may also prevent (left-hand side) or trigger
(right-hand side) an innate immune response
by interacting with specialized white blood
cells that are associated with the digestive
tract.
Taken together, these actions reduce the
presence of pathogenic organisms, reduce
their associated pathogen processes, and
improve the responsiveness of the immune
system. Those changes lead to better health
and performance whether you're measuring
weight gains, feed conversions, and efficiency of milk production, adverse health
events, or other production variables of economic importance.

Nφ
Mφ

1

Report of a joint FAO/WHO Expert Consultation.

Health and nutritional properties of probiotics in food in-

cluding powder milk with live lactic acid bacteria. ftp://
ftp.fao.org/docrep/fao/009/a0512e/a0512e00.pdf Cordoba, Argentina, October 2001
2

Report of a joint FAO/WHO Expert Consultation.

Guidelines for the evaluation of probiotics in food. http://
www.fda.gov/ohrms/dockets/dockets/95s0316/95s0316-rpt0282-tab-03-ref-19-joint-faowho-vol219.pdf
London, Canada, April 2002.

Dr. Steve Lerner is Vice President of Product Development and Commercialization
for Nutrition Physiology Company (NPC)
since 2013. He has a Ph.D. in Reproductive
Physiology from West Virginia University
and a post-doctoral Fellowship in Molecular Genetics from the University of Southern
California. He holds an M.S. in Biology/
Embryology from West Virginia University
and a B.S. in Zoology from University of
Maryland.
Reprinted with permission from Macmillan Publishers Ltd: Nature Reviews Gastroenterology and
Hepatology 7:10, M. Gareau, et al, Probiotics and
the gut microbiota in intestinal health and disease,
copyright 2010.

phoenixfeeds.net/magazine

Antimicrobial
factors


http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-rpt0282-tab-03-ref-19-joint-faowho-vol219.pdf http://www.phoenixfeeds.net/magazine

Perspectives - Winter 2016

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Contents
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