Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P96

Otology/Neurotology

P96
Otolaryngology-Head and Neck Surgery 163(1S)
Presentation schedule is subject to change. The Official Program Abstracts supplement does not reflect changes made after August 10, 2020.
patients who underwent pOAI from 2009 to 2019. Holger's
for evaluation of treatment efficacy regarding Eustachian tube
score was used as a means to classify soft-tissue complicaquality of life and Eustachian tube health in CS patients.
tions from 0 to 4. Outcome measures include Holger's score at
the first postoperative visit, total number of problem visits,
Expression of Antimicrobial Innate Immune
and subgroup analysis.
Molecules in Labyrinthitis: An Archival
Results: A total of 126 patients ([no tobacco exposure group
Human Temporal Bone Study
(NT): n = 73], [tobacco exposure group (T): n = 53]) underKaren Teufert, MD (Presenter); Fred H. Linthicum Jr, MD
went pOAI surgery in this study. The T group was found to
Objectives: We hypothesize that the inner ear is protected
have higher rates of first postoperative visit soft-tissue reacby an innate immune system and that antimicrobial innate
tions compared with the NT group (24.5% vs 6.8%, P = .011,
molecules are elaborated by the cellular components of the
odds ratio 4.42, 95% CI, 1.5-13.3). There was no difference
inner ear. It has been suggested by a number of investigators
in total number of problem visits (NT 76.3% vs T 79.2%, P =
that the endolymphatic sac is an immune organ. To investi.918). There was no difference in Holger's score between curgate the expression of antimicrobial innate immune molerent and prior smokers (P = .694).
cules by the epithelial cells of the endolymphatic sac, we
Conclusions: Patients with tobacco use have a significantly
used antigen-retrieval immunohistochemistry using archival
higher rate of skin reactivity compared with patients without.
human temporal bones from patients with histological eviInterestingly, both T and NT groups experience relatively high
dence of labyrinthitis.
rates of skin problems requiring office visits over the long
Methods: Immunohistochemistry using lysozyme, lactoferterm. Likewise, among the T group, smoking cessation does
rin, EP2E, and beta-defensin-1 and -2 antibodies was pernot confer protection against early skin reactivity. Surgeons
formed on 2 pairs of temporal bones from patients with
should be aware of the risks of early skin reactivity and should
labyrinthitis and 2 pairs of temporal bones from patients free
counsel patients accordingly.
of ear diseases as controls.
Results: Strong expression of lysozyme, lactoferrin, EP2E,
Eustachian Tube Dysfunction in Patients
and beta-defensin-1 and -2 was observed in the endolymphatic
With Severe Rhinosinusitis
sac epithelial cells of both temporal bones from patients with
Michela Borrelli (Presenter); Arash Shamsian; Stephanie
labyrinthitis. Endolymphatic sac epithelial cells of temporal
Hopp, MS, MPH; Masa Petrovic; Martin L. Hopp, MD, PhD
bones from patients free of ear disease (normal ears) expressed
Objectives: Disorders of the middle ear are prevalent in
lysozyme, lactoferrin and beta-defensin-1. As expected, this
patients with chronic sinusitis (CS). There have been few studexpression was weaker than the one observed in labyrinthitis
ies regarding the incidence of Eustachian tube dysfunction
patients. There was no staining with EP2E and beta--defensin-2
(ETD) in CS patients. We sought to determine the prevalence of
in the normal ears.
ETD in CS patients and the correlation between Eustachian
Conclusions: The epithelial cells of the endolymphatic sac
tube symptoms and CS symptoms using validated instruments.
contribute to the innate immune response of the inner ear by
Methods: Using the Sino-Nasal Outcome Test (SNOT-22),
expressing lysozyme, lactoferrin, EP2E, and beta-defensin-1
a 22-item validated sinus quality-of-life (QOL) instrument,
and -2. These findings show that the endolymphatic sac plays
we studied patients with moderate to severe CS. CS patients
an immunologic role and also suggest a similarity between the
were also given the Eustachian Tube Dysfunction
middle and inner ear innate immune response to inflammation.
Questionnaire (ETDQ-7), a 7-item validated QOL instrument.
The SNOT-22 and ETDQ-7 total scores were used to find the
Facial Nerve Outcome After Surgical
correlation between CS and ETD symptoms, and the inciResection of Vestibular Schwannoma
dence of ETD in CS patients.
Bridget Vivian MacDonald (Presenter); Yin Ren, MD, PhD;
Results: A total of 182 continuous CS patients were asked to
Kareem O. Tawfik, MD; Marc S. Schwartz, MD;
complete the ETDQ-7 and the SNOT-22. A total of 138
Rick A. Friedman, MD, PhD
patients (61 women and 77 men) completed both forms. Using
a cut-off score of >14.5 as an indication of abnormal health on
Objectives: The incidence of facial nerve (FN) dysfunction
the ETDQ-7, 60 of the 138 patients who completed the forms,
after vestibular schwannoma (VS) resection is variable. This
or 43.5%, were abnormal. Of the 61 women who completed
study aims to identify clinical factors and intraoperative findthe forms, 31 or 50.8% were abnormal and of the 77 men who
ings that could predict FN outcome.
completed the forms, 29 or 37.7% were abnormal. Spearman
Methods: A prospective study of patients undergoing VS
and Pearson correlation coefficients between the total SNOTsurgery from November 2017 to October 2019 at an aca22 and ETDQ-7 scores were 0.5610 (P < .001) and 0.5769 (P
demic quaternary care center was conducted. Demographics,
< .001), respectively.
operative approach, extent of resection, and intraoperative
Conclusions: This study shows that there is a strong and sigelectromyographic (EMG) monitoring data were collected.
nificant correlation between ETD symptoms and CS sympFN outcomes defined by House-Brackmann (HB) grades
toms. About half of women and a third of men suffering from
were stratified into good (HB I-II) and poor (HB III-VI)
CS also have symptoms of ETD. This information can be used
cohorts.

Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts

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