Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P99

Oral Presentations	

Human Otopathology of Age-Related
Ossicular Changes in Presbycusis
Prithwijit Roychowdhury (Presenter); Melissa CastilloBustamante; Marc Polanik; Elliott D. Kozin, MD; Aaron K.
Remenschneider, MD, MPH
Objectives: Age-related hearing loss (presbycusis) is a nearly
universal condition. The cause of presbycusis has been mainly
attributed to inner ear dysfunction; however, little is known
about the existence of age-related changes in the ossicular
joints. Herein, we undertake otopathologic analysis to describe
age-related ossicular joint findings in presbycutic patients.
Methods: Specimens from the National Temporal Bone
Registry with audiometrically documented presbycusis in life
were analyzed by light microscopy and histopathologically
described. Volumetric measurements of the incudomallear joint
(IMJ) synovial space were obtained after 3-dimensional reconstruction. Nonpathologic specimens younger than 50 years
were included as controls.
Results: Twelve patients (22 ears) and 6 controls (11 ears)
were examined. The mean age for the presbycusis group was
76.3 (SD 10.9, range, 59-93) and 27.7 (SD 8.3, range, 19-39)
for controls (P < .001). Histologic findings in the presbycutic
patients included tympanic membrane thickening, partial erosion of the malleolar head, fibrous degeneration of the ossicles, and ankylosis in the IMJ. These findings were absent in
controls. The IMJ synovial space was smaller in the presbycusis group compared with controls (0.032 [SD 0.011] vs 0.043
[SD 0.004], P = .003).
Conclusions: Otopathological analysis revealed ossicular
abnormalities in presbycutic patients not seen in controls. The

IMJ synovial space is reduced in presbycutic patients. This
finding suggests ossicular joint degeneration occurs in presbycusis. Further work should explore difference in middle ear
impedance and conductive hearing as a function of age.
Impact of Ambient Noise on Tablet-Based
Digits in Noise Hearing Screening
Diana Yunji Lee (Presenter); James E. Saunders, MD
Objectives: To help screen large populations for hearing loss
without specialized equipment or a sound booth, the World
Health Organization (WHO) developed the hear WHO mobile
application, which uses the Digits-in-Noise (DIN) method of
presenting digit-triplets over a background noise floor, a technology intended to be used in public places and is assumed to
be minimally affected by ambient noise. However, the effects
of ambient noise levels on DIN testing have not been studied;
our study determines the effects of elevated ambient noise on
DIN results in normal-hearing children and adults.
Methods: Twenty normal-hearing children (age 6-12 years)
and 20 normal-hearing adults (age 23-34 years) were administered a tablet-based WHO DIN hearing test. To replicate a
community screening environment, calibrated speech babble
ambient noise was presented in a sound booth. Each subject
performed the DIN test twice in quiet and at 45, 50, 55, 60, 65,
and 70 dBA noise levels in a random order. Both insert headphones and over-the-ear headphones were used in random
order. One-tailed paired t tests were performed between the
DIN performance score in quiet and at each noise level.
Results: DIN scores decreased in the presence of elevated
ambient noise in both pediatric and adult subjects. In children, a significant difference in performance was seen at
≥45 dBA (P < .01) for insert headphones and at ≥50 dBA
(P < .05) for over-the-ear headphones. In adults, a significant
difference in performance was seen at ≥55 dBA (P < .02) for
insert headphones and at ≥45 dBA (P < .05) for over-the-ear
headphones.
Conclusions: Tablet-based DIN testing is affected by ambient noise levels greater than 45 to 55 dBA. Screening results
above noise level are not reliable.
Impact of Treatment on Vestibular
Schwannoma-Associated Symptoms: A
Prospective Study Comparing Treatment
Modalities
Jason H. Barnes, MD (Presenter); Neil S. Patel, MD;
Michael J. Link, MD; Christine Lohse, MS; Nicole M. Tombers;
Matthew L. Carlson, MD
Objectives: The degree to which various treatment modalities prospectively modify vestibular schwannoma (VS)-
associated symptoms has received limited attention. Such
information could prove useful when counseling patients with
VS who endorse distressing symptoms and are seeking recommendations regarding management.
Methods: Patients with sporadic VS who received treatment
at the authors' institution were prospectively surveyed using a

Otology/Neurotology

histologic phenotype of facial nerve schwannomas in the
Postn-Cre;Nf2flox/flox mouse can help characterize the microenvironment of such tumors for future treatment investigations.
Methods: Microtome sectioning of paraffin-embedded
postn-Cre;Nf2flox/flox and control mice heads was performed
until the geniculate ganglion was identified in 3.5-µm-thick
sections. Sections were then mounted and analyzed with
hematoxylin/eosin or immunohistochemical staining to quantify Schwann cell cellularity and tumorigenesis.
Results: Postn-Cre;Nf2flox/flox mice and control littermates were euthanized at age 6, 9, and 12 months and tissues
fixed in 10% formalin. Comparative analysis of geniculate
ganglion cellularity on immunohistochemical staining showed
a progressive increase in the number of Schwann cell nuclei in
mutant mice. Tumorlets in Postn-Cre;Nf2flox/flox mutant
mice ganglions were significantly increased compared with
control littermates.
Conclusions: The Postn-Cre;Nf2flox/flox mouse model has
previously been described to develop cranial nerve schwannomas. Pathological Schwann cell tumor lesions in the geniculate ganglion of these mice demonstrates increased Schwann
cell cellularity and tumorigenesis. This phenotype characterization can help to establish a quantifiable readout for preclinical drug testing.

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Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts

Table of Contents for the Digital Edition of Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts

Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts
Contents
Accreditation Information
2020 President Duane J. Taylor, MD
2020 Annual Meeting Program Committee
2020 Star Reviewers
2020 Distinguished Service Award Recipients
2020 Honor Award Recipients
Honorary Guest Lecturers 2020
Panel Presentations
Oral Presentations
Poster Presentations
Author Index
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Intro
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Cover2
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - A1
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - A2
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - A3
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Contents
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - A5
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - A6
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Accreditation Information
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - 2020 President Duane J. Taylor, MD
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - 2020 Annual Meeting Program Committee
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P4
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - 2020 Star Reviewers
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - 2020 Honor Award Recipients
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P7
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Honorary Guest Lecturers 2020
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P9
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Panel Presentations
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P11
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P12
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P13
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Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P45
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Oral Presentations
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P47
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P48
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P49
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Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Poster Presentations
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Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P271
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P272
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P273
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P274
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P275
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P276
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P277
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P278
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P279
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P280
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P281
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P282
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P283
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P284
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P285
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P286
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P287
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P288
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P289
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P290
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P291
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P292
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P293
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P294
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P295
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P296
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P297
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P298
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P299
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P300
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P301
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P302
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P303
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P304
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P305
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P306
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P307
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P308
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P309
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P310
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P311
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P312
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Author Index
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P316
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P317
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P318
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P319
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P320
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P321
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P322
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P323
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P324
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P325
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P326
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P327
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P328
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P329
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P330
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P331
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P332
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Cover3
Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - Cover4
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