Magnetics Business & Technology - July/August 2021 - 21

RESEARCH & DEVELOPMENT
Knobby Magnetic Beads from ITRI in Taiwan Show Promise for Fighting Cancer
medical centers and biotech companies using
iKNOBEADS manufacturing technology
as a platform. ITRI aims to launch clinical
GMP products in the future to apply the
beads and manufacturing technology to a
variety of immunotherapies, particularly to
solid cancers.
Their work has garnered accolades, including
a prestigious Edison Award last year
which recognized iKNOBEADS as " a gamechanging
innovation standing out among the
best new products and services launched in
their category. " Based in Hsinchu, ITRI is a
leading applied technology research institute
with a staff of more than 6,000 people
which has incubated numerous commercial
spinouts. Nearly 90% of the lab's scientists
and staff members hold master's or higher
degrees, with more than 100 of them being
PhD's.
ITRI's iKNOBEADS can activate T cells to fight cancer cells more effectively, becoming a
new tool in immunotherapies.
Knobby knees may be a drawback to a fashion model, but knobby
magnetic beads look quite attractive for battling
certain types of cancer. That's what scientists at
Taiwan's Industrial Research Institute of Technology
(ITRI) have found in their work developing precision
tools for medicine. They have developed the
world's only biomimetic knobby magnetic beads.
The iKNOBEADS are irregularly protruded-looking
spiky balls that can strengthen and magnetically
activate T cells to fight cancer cells more effectively.
Magnetic beads typically are involved in in vitro
activation, which is a mainstream method presently
used in immunotherapies. Commercially available
magnetic beads are spherical. These beads, however,
feature a unique spiky structure, enhancing
the activation efficacy and expanding the number
of T cells by a factor of 100.
The number of beads required is only one-third that
of the magnetic beads currently on the market, say
the researchers. The beads can make dormant T
cells come alive, have memory-like functions, and
lead the fight against cancer cells. By modifying
the surface of the magnetic beads, the manufacturing
technology can be applied to the activation
and expansion of lymphoma cells, becoming the
world's first and only magnetic bead product of this
type, they report.
Currently, the research team is focused on therapies
for hematological cancers such as blood cancer,
lymphoma and bone cancer. It has discussed
cooperation with a number of local and foreign
www.MagneticsMag.com
July/August 2021 * Magnetics Business & Technology 21
For more info, see www.itri.org.tw.
http://www.itri.org.tw http://meda.com/ http://www.MagneticsMag.com

Magnetics Business & Technology - July/August 2021

Table of Contents for the Digital Edition of Magnetics Business & Technology - July/August 2021

Magnetics Business & Technology - July/August 2021
Editor’s Choice/ Features
Major Automakers Transform Design & Manufacturing Operations on Accelerated Path to e-Propulsion – Part 2 of 2
Luxury Auto Maker Bentley Goes After Magnet Materials & Manufacturing Advancements
Magnetism Plays Key Roles in DARPA Research to Develop Brain-Machine Interface without Surgery
Research & Development
Product News
Industry News
Events Calendar/ Advertising Index
Toshiba’s New Magnetic Material Improves Motor Energy Conversion Efficiency
Visions
Magnetics Business & Technology - July/August 2021 - Magnetics Business & Technology - July/August 2021
Magnetics Business & Technology - July/August 2021 - Cover2
Magnetics Business & Technology - July/August 2021 - 3
Magnetics Business & Technology - July/August 2021 - Editor’s Choice/ Features
Magnetics Business & Technology - July/August 2021 - 5
Magnetics Business & Technology - July/August 2021 - Major Automakers Transform Design & Manufacturing Operations on Accelerated Path to e-Propulsion – Part 2 of 2
Magnetics Business & Technology - July/August 2021 - 7
Magnetics Business & Technology - July/August 2021 - 8
Magnetics Business & Technology - July/August 2021 - 9
Magnetics Business & Technology - July/August 2021 - 10
Magnetics Business & Technology - July/August 2021 - 11
Magnetics Business & Technology - July/August 2021 - Luxury Auto Maker Bentley Goes After Magnet Materials & Manufacturing Advancements
Magnetics Business & Technology - July/August 2021 - 13
Magnetics Business & Technology - July/August 2021 - 14
Magnetics Business & Technology - July/August 2021 - 15
Magnetics Business & Technology - July/August 2021 - Research & Development
Magnetics Business & Technology - July/August 2021 - 17
Magnetics Business & Technology - July/August 2021 - 18
Magnetics Business & Technology - July/August 2021 - 19
Magnetics Business & Technology - July/August 2021 - 20
Magnetics Business & Technology - July/August 2021 - 21
Magnetics Business & Technology - July/August 2021 - Product News
Magnetics Business & Technology - July/August 2021 - 23
Magnetics Business & Technology - July/August 2021 - 24
Magnetics Business & Technology - July/August 2021 - 25
Magnetics Business & Technology - July/August 2021 - Industry News
Magnetics Business & Technology - July/August 2021 - 27
Magnetics Business & Technology - July/August 2021 - 28
Magnetics Business & Technology - July/August 2021 - 29
Magnetics Business & Technology - July/August 2021 - 30
Magnetics Business & Technology - July/August 2021 - 31
Magnetics Business & Technology - July/August 2021 - Events Calendar/ Advertising Index
Magnetics Business & Technology - July/August 2021 - 33
Magnetics Business & Technology - July/August 2021 - Visions
Magnetics Business & Technology - July/August 2021 - Cover3
Magnetics Business & Technology - July/August 2021 - Cover4
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