Magnetics Business & Technology - September/October 2021 - 12

FEATURE ARTICLE
Magnetofection Products from OZ Biosciences Advance Biotech Research, Development of New
Medicines
Look around life science laboratories most anywhere in the world
and before long you will likely come across magnetic reagents
along with a few specially designed magnetic kits and laboratory
tools from OZ Biosciences. The company's Magnetofection technology
is playing an important role in advancing biotech research
and the development of new medicines as its precisely designed
iron oxide nanoparticles gain ever more specificity in targeting
molecules under scrutiny.
OZ Biosciences focuses on delivery technologies for biomolecules
such as DNA, RNA and protein for the worldwide scientific
community and pharmaceutical industry. Tucked away in a picturesque
scientific and technology park on the outskirts of Marseilles,
France, the company has been developing innovative molecular
delivery systems since 2003.
The period has been a time of technological revolutions for the life
sciences. The progress achieved in genomic, functional genomic
and proteomic areas has created fabulous opportunities for better
understanding of basic biological processes and for the development
of the next generation of medicines. Lately, application
of Magnetofection to whole, living organisms has been receiving
particular attention.
In vivo Magnegofection
The company's extensive line of such products is based around
biodegradable magnetic nanoparticles made of iron oxide that are
coated with specific proprietary cationic molecules varying upon
applications. The principle is to associate nucleic acids, transfection
reagents or viruses with specific magnetic nanoparticles. The
resulting molecular complexes are then concentrated and transported
into cells supported by an appropriate magnetic field. In
this way, the exploitation of a magnetic force exerted upon gene
vectors allows a very rapid concentration of the entire applied vector
dose on cells, so that 100% of the cells get in contact with a
significant vector dose, and promotes cellular uptake.
The technology has become a simple and highly efficient method
to transfect primary cells and hard to transfect cells, inspired by
validated and recognized magnetic drug targeting methods. An
array of application specific reagents has been developed by the
company for both in vitro use, meaning outside of a living organism,
initially, and now also for in vivo use, meaning within an entire
living organism.
In vitro Magnetofection process
Lately, OZ Biosciences' in vivo solutions have received particular
attention. Designed for in vivo targeted transfection and infection,
the system combines magnetic nanoparticles and nucleic
acid vectors that will be retained after injection at the magnetically
targeted site. In this way, targeted delivery minimizes systemic
12 Magnetics Business & Technology * September/October 2021
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Magnetics Business & Technology - September/October 2021

Table of Contents for the Digital Edition of Magnetics Business & Technology - September/October 2021

Magnetics Business & Technology - September/October 2021
Editor’s Choice/ Features
Reduced-Helium Magnets from Philips a Game-Changer in MRI Scanners
Driven by Global Pandemic, Magnetic Diagnostics Tools from Luminex Take Part in 98% Jump in Business
World’s Most Powerful Tidal Turbine Launched Offshore Scotland
Research & Development
Product News
Industry News
Events Calendar/ Advertising Index
Magnetic Levitation Studied at JPL for Moving Payloads Around the Moon
Visions
Magnetics Business & Technology - September/October 2021 - Magnetics Business & Technology - September/October 2021
Magnetics Business & Technology - September/October 2021 - Cover2
Magnetics Business & Technology - September/October 2021 - 3
Magnetics Business & Technology - September/October 2021 - Editor’s Choice/ Features
Magnetics Business & Technology - September/October 2021 - 5
Magnetics Business & Technology - September/October 2021 - Reduced-Helium Magnets from Philips a Game-Changer in MRI Scanners
Magnetics Business & Technology - September/October 2021 - 7
Magnetics Business & Technology - September/October 2021 - Driven by Global Pandemic, Magnetic Diagnostics Tools from Luminex Take Part in 98% Jump in Business
Magnetics Business & Technology - September/October 2021 - 9
Magnetics Business & Technology - September/October 2021 - 10
Magnetics Business & Technology - September/October 2021 - 11
Magnetics Business & Technology - September/October 2021 - 12
Magnetics Business & Technology - September/October 2021 - 13
Magnetics Business & Technology - September/October 2021 - 14
Magnetics Business & Technology - September/October 2021 - 15
Magnetics Business & Technology - September/October 2021 - World’s Most Powerful Tidal Turbine Launched Offshore Scotland
Magnetics Business & Technology - September/October 2021 - 17
Magnetics Business & Technology - September/October 2021 - Research & Development
Magnetics Business & Technology - September/October 2021 - 19
Magnetics Business & Technology - September/October 2021 - Product News
Magnetics Business & Technology - September/October 2021 - 21
Magnetics Business & Technology - September/October 2021 - 22
Magnetics Business & Technology - September/October 2021 - 23
Magnetics Business & Technology - September/October 2021 - 24
Magnetics Business & Technology - September/October 2021 - 25
Magnetics Business & Technology - September/October 2021 - Industry News
Magnetics Business & Technology - September/October 2021 - 27
Magnetics Business & Technology - September/October 2021 - 28
Magnetics Business & Technology - September/October 2021 - 29
Magnetics Business & Technology - September/October 2021 - 30
Magnetics Business & Technology - September/October 2021 - 31
Magnetics Business & Technology - September/October 2021 - Events Calendar/ Advertising Index
Magnetics Business & Technology - September/October 2021 - 33
Magnetics Business & Technology - September/October 2021 - Visions
Magnetics Business & Technology - September/October 2021 - Cover3
Magnetics Business & Technology - September/October 2021 - Cover4
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