Tumori Journal Abstract Book - October 2020 - 177

T - Miscellanea	
glycaemia (p<0.001) and triglycerides (p<0.001), both
maintained at second FU (p=0.016 and p<0.001). At
6-month,46.2% of participants declared an increase in
physical activity, over 80.0% reduced the use of processed
and red, while 60.5% increased the intake of legumes and
43.7% of whole cereals. Higher diet scoring associated to
improvements in BMI (OR 1.20; 1.02-1.41) and waist circumference (OR 1.32; 1.11-1.56).
Conclusions: At follow-ups, results show improvements
in diet, physical activity and anthropometric parameters.
These results are encouraging, but need further assessment
for long-term maintenance. The Oncology Network of
Piemonte and Valle d'Aosta will plan to provide a practical
guidance to be included in oncology treatment paths.

T03
Contrasting fake news in
oncology: the first Declaration
of Good Communication
Caporossi M.1, Papa R.2, Scandali V.M.2, Torniai M.3, Blasi M.4,
Brusa A.5, Elisei F.6, Gregori G.L.7, Laurenzi G.8, Marinelli L.7,
Marinelli M.9, Mazzoli G.10, Volpini F.11, Berardi R.12
1
General Director - AOU Ospedali Riuniti di Ancona, Via Conca 71, 60126
Ancona, Italy, Ancona; 2Healthcare Medical Direction, AOU Ospedali Riuniti
di Ancona, Ancona; 3Oncology Clinic, Università Politecnica delle Marche,
AOU Ospedali Riuniti di Ancona, Ancona; 4Chief Editor RAI TGR Marche,
Ancona; 5Il Resto del Carlino, Ancona; 6President of Order of Journalists
- Regione Marche, Ancona; 7Department of management, Università
Politecnica delle Marche, Ancona; 8Deputy Director of "Il Messaggero" and
Director of "Corriere Adriatico", Ancona; 9Primary Care Physician, Bioethicist
and Professor of Narrative Medicine, Ancona; 10Università degli studi di
Urbino Carlo Bo, Urbino; 11President of IV Commissione Salute Regione
Marche and Primary Care Physician, Ancona; 12Oncology Clinic, Università
Politecnica delle Marche, AOU Ospedali Riuniti di Ancona, Via Conca 71,
60126 Ancona, Italy, Ancona

Background: In the ongoing fight against diseases, healthcare professionals ought to make use of any weapon, together
with the fundamental role of scientific research. Nowadays,
websites, online journals and social media give access to an
extraordinary amount of medical information; moreover,
many patients and their families employ media searching for
additional clarifications about their own malignancies and
the prescribed treatments. Even on officially supported websites, misleading news might be disseminated generating
false expectations, exaggerated anxiety and confusion. In
oncology setting, disinformation is perhaps more deleterious
than in other fields, with a considerable impact on single
patients and, more in general, on Public Health.
Materials and Methods: In order to promote the best
interaction between the world of health and the world of
communication, a table of experts was established with the
aim to draft a shared document identifying strategies to
overcome barriers between communication and healthcare
as well as to propose common criteria for an effective

177
dissemination of medical information. On the basis of the
"consensus conference" method in the RAND/UCLA variant (a modified version of Delphi methodology), a literature research has been conducted with the aim to select
studies related to the best practices applied to health journalism regarding oncology setting.
Results: Sixteen articles met the inclusion criteria, from
which 72 recommendations were extracted and submitted
to experts in communication and healthcare professionals
included in the technical table. After panel evaluation, 57
recommendations scored more than 7 representing the
selected statements shared together by communication
experts and healthcare professionals.
Conclusions: This consensus and the drawn up shared
document represent a concrete attempt to found a renewed
and strategic alliance between healthcare and communication operators in order to produce useful and reproducible
indications for an effective dissemination of medical information. As the "American Declaration of Independence",
our "Declaration of Good Communication" has identified
high-impact recommendations for the best management of
patients, providing simple but fundamental concepts and
recommendations about effective communication, especially in oncology setting.

T04
Functional inactivation of
E-cadherin by Trop-2 drives cancer
metastasis
Alberti S.1, Guerra E.2, Lattanzio R.2, Ceci M.2, Boujnah K.1, Briguori
S.1, Garbo V.1, Moschella A.1, Altomare D.3, Depalo R.3, Rotelli M.T.3,
Picciariello A.3, Trerotola M.2
1

Università di Messina, Messina; 2Università di Chieti, Chieti; 3Università di
Bari, Bari

Background: Tumor metastasis is the main cause of death
of cancer patients and the biggest hurdle for cancer cure.
The identification of decisive drivers of metastasis and that
of pivotal therapy targets is thus an urgent need.
Material (patients) and methods: Immunofluorescence
confocal microscopy and flow cytometry analysis were
utilized to quantify expression of target proteins, IHC
analysis quantified the expression of target molecules in
primary tumors and metastases. Cell-cell adhesion capacity was explored in vitro and in cancer cell spheroid models. Pre-clinical models of orthotopic growth of colon
cancer and metastatic diffusion to the liver were utilized.
Xenotransplant transcriptome analysis assessed EMT
determinant transcription. Patients: 24 distinct case series
of breast, colon, uterus, ovary, stomach, lung, and pancreatic cancers, for a total number of 13,042 primary tumors
were analyzed. Kaplan-Meier plots were used to illustrate
survival and metastatic relapse in investigated cohorts.
Tumori Journal Abstract Book - October 2020

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