Tumori Journal Abstract Book - October 2020 - 203

T - Miscellanea	
was organized and measures of screening and prevention
were adopted: informative letter to family doctor, panoramic radiography and dental examination.
Objectives: This analysis evaluate an unselected cancer
patients frequency and risk factor or comorbidities that
could lead DMAB associated ONJ.
Results: Since November 2017 to march 2020 we evaluated 78 patients: 29 M and 49 F; median age 66 (range
31-81). Most oncologic diagnoses included breast cancer
(20%), NSCLC (30%), SCLC (10%), prostatic cancer
(20%) and others (20%). Patients were analyzed according
to demographic, oncotypes, concurrent medications and
duration of DMAB therapy.
Conclusions: We have found 2 (1.5%) new cases of ONJ:
2 NSCLC and 1 breast cancer and in all patients the lesion
was found in the mandible. Presentation symptom was
pain and the most common found risk factors were prolonged duration of DMAB therapy and concurrent corticosteroid use. ONJ is rare in patients treated with DNSB
but in any case is a serius complication for oncological
patients and requires an accurate diagnosis and an appropriate therapy. Prevention measures and patients education
seem to decrease ONJ risk.

203
Results: 27/93 pts (29%) had mild CRF, 54/93 (58%)
moderate and 12/93 (12.9%) severe. Regarding mild CRF,
9 pts (33.3%) had pain symtoms, 15 (55.5%) BMI >25.
Regarding moderate CRF, 48 pts (88.8%) had pain symptoms, 46 (85.1%) BMI> 25. Pts with severe CRF, 9 (75%)
had pain symptoms and 10 (83.3%) BMI>25.
Conclusions: Our results suggest that in pts with advanced
solid tumours treated with immunotherapy, moderate and
severe fatigue is associated with greater pain symptoms
and elevated BMI.

T54
A source of Mortality Data
to broaden the territorial
knowledge of the Asl Napoli 1
Centro. Epidemiological study
on the Palliative homecare in
cancer to create risk maps of the
territory and develop prevention
plans
Rossiello R.1, Sorrentino I.2, Maddalena A.2, Gallo P.2, De Sangro C.2
1

T53
Correlation between Fatigue,
Pain Symptoms and BMI in
immunotherapy in solid tumours
Fontana A.1, Rossi L.2, D'Assisi Cardillo F.3, Angelini F.4, Tomao S.5,
Gozzi E.2
1

Ospedale Santa Maria Goretti, Latina; 2Università la Sapienza di Roma,
Aprilia; 3Ospedale Dono Svizzero, Formia; 4Ospedale Regina Apostolorum
Albano laziale, Albano; 5Università la Sapienza di Roma, Roma

Background: Fatigue is one of the main symptoms in cancer patients. In most cases its etiopathogenesis is multifactorial or treatment-related with unknown pathophysiologic
abnormalities. However, several factors can contribute to
cancer-related fatigue (CRF) such as: anemia, pain, insomnia, depressive symptoms, and elevated BMI.
The aim of our study was to evaluate CRF and its correlation with pain symptoms and BMI in immunotherapy in
solid tumours.
Patients and methods: We enrolled 93 patients (pts) with
advanced solid tumours treated with immunotherapy. 80
pts (86%) had non-small-cell lung carcinoma (NSCLC), 4
(4.3%) had renal cell carcinoma (RCC) and 9 (9.6%) bladder cancer. Mean age was 70 years (range 48-82). We used
a simple visual analog scale (VAS) with anchors of 0 and
10 (with 0 as no fatigue and 10 as the worst imaginable
fatigue) to evaluate CRF. Pts were divided into groups
based on CRF value: mild (0-3), moderate (4-6)
severe(7-10). Then we correlated CRF with pain symptoms ( presence or absence) and BMI (< 25 or >25).

Ospedale S.P.S. San Gennaro di Napoli, Napoli; 2Ospedale S.P.S. San
Gennaro di Napoli, Napoli

Bckground: Over the past decade there has been a profound epidemiological and clinical change in patients,
especially in areas considered "polluted"; the appearance
of tumors, aggressive and at an earlier age and the increase
in the possibility of treating oncological pathologies has
brought with it the growth of patients in "partial remission" which often become more complicated over time,
leading to cases of "incurability" which open space to the
typical issues of palliative medicine.
Matherial and Methods: A database of 485 cancer patients
being treated at the UOSD Palliative Home Care, who died
in 2018, was taken into consideration. The variables used
are the following: 1) General data regarding patients,
workload and its distribution; 2) Specific data concerning
the setting of palliative therapy; 3) Pain and its evaluation
(pain evalutated according to NRS scale); 4)"Risk Areas"
(geographical areas limited to roads or neighborhoods for
tumor mapping).
Results: An analysis of the Mortality data revealed:
-	 The prevalence of lung and colon cancer in the area
adjacent to the Pianura landfill is relevant, for
example we have found cases of cancer in different
patients coming from the same ways of residence.
Given the highest prevalence of advanced tumors in
the non-elderly age = 64 years.
-	 We also found an increase in so-called "emerging"
tumors, with a higher prevalence than in previous
years, and for this reason we compared the cases of
liver cancer with Glioblastoma. On the one hand we
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