Tumori Journal Abstract Book - October 2020 - 23

A - Thoracic Cancers	

23

Table 1.  Characteristics of LC patients enrolled in the study
(N=243).
Characteristics
Age at diagnosis
Median [DS]
Gender
Male
Female
Histology
Adenocarcinoma
Squamous carcinoma
Other
Stage at diagnosis
IV
I-III
Performance Status (ECOG)
0
1-2
Metastatic at study enrollment
Yes
No
Treatment for metastatic disease
Chemotherapy
Immunotherapy
Target Therapy

N (%)
67.3 [±9.0]
153 (63.0)
90 (37.0)
174 (71.6)
54 (22.2)
15 (6.2)
106 (43.6)
137 (56.4)
132 (54.3)
111 (46.7)
127 (52.3)
116 (47.7)
68 (53.5)
26 (20.5)
33 (26.0)

A34
Main genetic alterations
in a series of about 1500
Sardinian patients with lung
adenocarcinoma
Colombino M.1, Paliogiannis P.2, Doneddu V.2, Cossu A.2, Sardinian
Lung Cancer (SLC) S.G.2, Casula M.1, Sini M.C.1, Palomba G.1, Pisano
M.3, Manca A.3, Rozzo C.3, Palmieri G.3
1

ICB-CNR, Sassari; 2AOU, Sassari; 3IRGB-CNR, Sassari

Background: Lung cancer is one of the most incident neoplastic disease, and a leading cause of death for cancer
worldwide. Knowledge of the incidence of genetic alterations, their correlation with clinical and pathological features of the disease, as well as their interplay in cases of
co-occurrence is crucial for selecting the best clinical management of patients with lung cancer. In this real-life study,
we describe the molecular epidemiology of genetic alterations in five driver genes, and their correlations with the
demographic and clinical characteristics of Sardinian
patients with lung adenocarcinoma.
Methods: 1,440 consecutive Sardinian patients with a histologically proven diagnosis of lung adenocarcinoma
made from January 2011 through July 2016 were included
in the study. EGFR mutation analysis was performed for
all of them, while KRAS and BRAF mutations were
searched in 1,047 cases; ALK alterations were determined
with fluorescence in situ hybridization in 899 cases, and

cMET amplifications in 788 cases. Testing was dictated by
the gradual introduction of the single analyses in clinical
practice, and the availability of sample tissues for testing.
Results: KRAS mutations were the most common genetic
alterations involving 22.1% of the cases and being mutually exclusive with the EGFR mutations, which were
found in 12.6% of them. BRAF mutations, ALK rearrangements, and cMET amplifications were detected in
3.2%, 5.3%, and 2.1% of the cases, respectively.
Concomitant mutations were detected only in a few cases.
Conclusions: Almost all the genetic alterations studied
showed a slightly lower incidence in comparison with
other Caucasian populations. Concomitant mutations
were rare, and they probably have a scarce impact on the
clinical management of Sardinians with lung adenocarcinoma. The low incidence of concomitant cMET amplifications at diagnosis suggests that these alterations are
acquired in subsequent phases of the disease, often during
treatment with TKIs.

A35
Statins and immunotherapy:
togetherness makes strength. The
Potential Effect of Statins on
Immunotherapy for NSCLC
Rossi A.1, Filetti M.2, Mazzotta M.2, Piras M.2, Taurelli Salimbeni B.2,
Rizzo F.2, Marchetti P.2, Giusti R.2
1
AO Sant'Andrea-Sapienza Univeristà di Roma, Roma; 2AO Sant'AndreaSapienza Università di Roma, Roma

Background: Statins are commonly used agents in primary and secondary prevention of cardiovascular disease,
but recent studies suggested that they can display pleiotropic effects on several cancer-related cellular processes,
such as proliferation, apoptosis, angiogenesis, and metastasis. Even though the promising molecular features,
results of randomized clinical trials investigating the combinations between statins and anticancer treatments have
been controversial so far. A recent meta-analysis of observational studies and randomized clinical trials suggested
that statins could positively affect the risk of all-cause
mortality and improve OS in lung cancer patients; conversely, no influence on PFS and overall response rate was
observed. Preclinical studies suggested that these drugs
could synergize with immunotherapy in the treatment of
lung cancer. However, a large cohort study that could help
validate these findings is still lacking in clinical practice.
Given the encouraging in vitro and in vivo results of available evidence, we analyzed the data collected from 162
patients treated with immunotherapy for Non-small Cell
Lung Cancer (NSCLC) in I and II line setting.
Materials and methods: In this observational study, we
enrolled 162 Lung cancer patients who were treated at our



Tumori Journal Abstract Book - October 2020

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