Tumori Journal Abstract Book - October 2020 - 90

90	

Tumori Journal 106(2S)

Results: From 20th April to 4th May 2020, 96 healthcare
workers [60 female, 36 male, median age 46 (28-70)] were
invited to participate to the integrated self-administered
questionnaire. The results of the IES test were in 42 (44%)
cases not clinically significant while in 19 (20%), 9 (9%)
and 26 (27%) there was a light, moderate and severe emergency impact respectively. The BAI test indicated a state
of anxiety in 76 (79%), 14 (15%) and 6 (6%) respectively
as mild, moderate and high. The BDI-II test indicated
depression in 71 (74%), 12 (13%), 6 (6%) and 7 (7%) as
low, mild, moderate and severe, respectively. The results
of the IES and BAI test had a Pearson correlation index of
0.81, while between IES and BDI-II was 0.71. A multiple
linear regression analysis between the dependent variable
IES and the independent variables BAI and BDI-II showed
an adjusted R-square index of 0.66 (p<0.000001).
Conclusions: Applied test results show likely effectiveness in assessing the emotional impact of the COVID-19
emergency. Moreover, having a strong correlation between
them and considering the measures of anxiety and depression as independent variables, these seem to be a predictive factor of the event's impact perception in the study
population. These results encourage to underline the
importance of adequate psychological support for health
workers even after the acute phase of the emergency.

adjuvant and 7% neoadjuvant/perioperative and type of txs
(32% immunotherapy). There were 26 delay in second
cycles, 24 in third and only 2 in fourth. In 18 cases delay
was scheduled to minimize risk of COVID19 contagion.
Expected neutropenia risk did not significantly influenced
delay, while age influenced in pts over 60 (13,3% of delay
in 80-90 group, 13,3% in 70-79, 17,3% 60-69 and 5,3% in
50-59). Adjuvant txs showed greater delays than metastatic and neoadjuvant /perioperative. 14% of immunotherapies (no difference in lung cancer vs others) was
delayed vs 16% of other txs.
Conclusions: The SAR-CoV2 pandemic infection obligated oncologists to establish the risk/benefit ratio of a
delay in txs, in absence of data. In our experience, the
age> 60 and adjuvant setting have more often delayed txs,
while type of therapy and the risk of neutropenia have had
less impact. In contrast to cancer society's recommendations, there have been no greater delays in immunotherapy
in lung cancer than in other diseases. The delay was more
frequent in the first phase of the pandemic, probably due to
the progressive reorganization of the cancer department
References
1-Liang W, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol 2020;
published online Feb 14
2-Wang H, Zhang L. Risk of COVID-19 for Patients With
Cancer. Lancet Oncol 2020 Apr;21(4): e181.

D47
SARS-CoV2 PANDEMIA AND DELAYED
CANCER TREATMENT: A SINGLE CENTRE
EXPERIENCE
1

1

1

1

1

Pellegrini E. , Modesti M. , Botteri C. , Doni L. , Pillozzi S. ,
Antonuzzo L.1
1

Azienda Ospedaliero-Universitaria Careggi, Firenze

Background: Pandemic SARS-CoV2 infection was characterized by a severe respiratory syndrome whit a worst
course in elderly with comorbidity. Oncology patients (pts)
may be at risk for an unfavorable course of infection (1). For
this, oncologists had to choose how maintaining therapeutic
benefit, minimizing risk of treatments (txs). Oncologist
associations had recommended to reduce risk but encouraging continuation of txs. Indeed, one of the risks for oncological pts was inability to receive necessary medical service
(2). In this study we reported our experience.
Methods: We analyzed pts with solid tumors which
received 1 cycle of therapy from 9 to 30 March 2020 at
Medical Oncology Unit of Azienda Ospedaliero
Universitaria Careggi. We subsequently followed pts over
time to evaluate delays in subsequent cycles, and its cause
(COVID19 or not related).
Results: We analyzed 118 pts (27% affected by lung cancer), divided in age groups (172 were over 50, 96 over 70
and 16 over 80), setting (86% metastatic disease, 8%

D48
Oral therapy prescription for
oncological patients during SArsCoV-2 pandemia
Petrella M.C.1, Palmieri V.E.2, Paderi A.2, Rossi G.2, Pillozzi S.2, Doni
L.2, Antonuzzo L.2
1
Medical Oncology Unit AOU Careggi, Firenze; 2Medical Oncology Unit, AOU
Careggi, Firenze

Background: The Sars-CoV-2 pandemic led to a reorganization of all hospitals activities and assistance to cancer
patients has also undergone changes. Our Medical Oncology
Unit-AOU Careggi, in the lockdown phase, has provided
guidelines to assist patients who receive oral cancer treatment with "telemedicine". Aim of this work is to analyze the
different ways in which the oncological visits scheduled for
the prescription of oral therapy were performed.
Material and methods: We consulted the agenda of
oncology visits for oral therapies scheduled between 09
March and 26 March 2020: 115 patients were included in
the study. We retrospectively compared the agenda with
the medical records. Most of the patients (74%) scheduled
in March followed a 28-day dosing schedule (q28), 13.04%
q21, for the remainder the control was less frequently.
Moreover, we also recorded subsequent visits, until May



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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