IJT - CIR - February 2024 - 104S

104S
International Journal of Toxicology 43(Supplement 1)
Figure 3. Metabolic fate of Triethylhexyl Trimellitate following oral dosing in the rat.2
Repeated Dose Toxicity
In repeated dose oral toxicity studies in rats, the noobserved-adverse-effect-level
(NOAEL) of tricaprylyl/
capryl trimellitate was 300 mg/kg/day in a 28-day gavage
study (a slight but statistically significant increase in absolute
and relative liver weights was observed in males and
females dosed with 1000 mg/kg/day), and it was 500 mg/kg/
day in a 13-wk gavage study29 (Table 6). Triethylhexyl
trimellitate was administered to rats by gavage for 21 days
(up to 2000 mg/kg/day)39,40 or 28 days (up to 1000 mg/kg/
day),39,41,42 andinthe diet (upto 2%) for28 days and (up to
1000 mg/kg/bw) for 90 days.32 In the feed study, hepatomegaly
was reported with .67 and 2.0% triethylhexyl
trimellitate; no significant test-article related effects were
reported in the other studies. The NOAEL in the 90-day
study was 225 mg/kg bw/day; some effects were observed in
liver and spleen weights.
Hepatotoxicity
In Vitro
Triethylhexyl Trimellitate. Hepatocytes from maleWistar rats
were incubated with 50 µg/mL triethylhexyl trimellitate in
polysorbate 80, and viability was evaluated by the Trypan blue
exclusion test.43 Cell viability was similar to controls over a
3 h period.

IJT - CIR - February 2024

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IJT - CIR - February 2024 - Cover3
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