IJT - CIR - February 2024 - 105S

Fiume et al.
105S
Table 5. Acute Toxicity Studies.
Ingredient
tricaprylyl/
capryl
trimellitate
triethylhexyl
trimellitate
triethylhexyl
trimellitate
tricaprylyl/
capryl
trimellitate
tricaprylyl/
capryl
trimellitate
SpragueDawley
rats
5
or 10 M undiluted 10 mL/kg bw (5 M) or 13.3-31.6 mL/
kg bw (10 M) by gavage
SpragueDawley
rats
NZW
rabbits
Wistar
rats
5M/5F
Animals
No./Group Vehicle
5M/5F
guinea pigs 1 (sex not
specified)
3M/3F
Concentration/Dose/Protocol
DERMAL
LD50/Results
undiluted Single 24 h semi-occlusive patches; 2
g/kg bw applied
undiluted Single 24 h occlusive patch; 5, 10, or
20 mL/kg
undiluted Single 24 h occlusive patch; 2.0 mL/kg
was applied
ORAL
undiluted 3 g/kg bw by gavage
>3 g/kg
No mortality and no signs of
toxicity
24.9 mL/kg bw
17.8 mL/kg: 3 animals died 6-7
days after dosing;
23.7 mL/kg: 3 animals died 3-6
days after dosing;
31.6 mL/kg: 8 animals died 3-9
days after dosing;
Signs of toxicity, primarily
reduced spontaneous
activity and soft feces, were
observed in all groups.
tridecyl
trimellitate
triethylhexyl
trimellitate
triethylhexyl
trimellitate
triethylhexyl
trimellitate
triethylhexyl
trimellitate
triethylhexyl
trimellitate
triethylhexyl
trimellitate
triisodecyl
trimellitate
triethylhexyl
trimellitate
triethylhexyl
trimellitate
Wistar
albino
rats
mice
mice
Crj:CD
(SD)
rats
SpragueDawley
rats
SpragueDawley
rats
SpragueDawley
rats
SpragueDawley
rats
rats
5M/5F
2M/2F
undiluted
5 g/kg bw by gavage
not
provided
not provided not
provided
10 (M and F) corn oil 0 and 2 g/kg by gavage; 40.0 w/v% for 2
g/kg dose
2M/2F
5M/5F
2M/2F
undiluted 10 mL/kg bw by gavage
undiluted 5 g/kg bw by gavage
undiluted 10 mL/kg bw by gavage
2M/2F
undiluted 10 mL/kg by gavage
INHALATION
3 (sex not
specified)
SpragueDawley
rats
5M/5F
Abbreviations:
NZW, New Zealand White.
230, 2640, or 4170 mg/m3 heated to
180°C to generate a mixture of
aerosol and heated vapor; wholebody
inhalation; 6-h exposure
2600 mg/m3; 4-h exposure
LC50 not determined
100% mortality at >2640 mg/
m3
>2600 mg/m3
No mortality and no signs of
toxicity
38
37
>2 g/kg
No mortality and no signs of
toxicity
>3.2 g/kg piloerection
observed in males at 1 and
2h
>5 g/kg
No mortality and no signs of
toxicity.
9.85 g/kg piloerection
observed in males at 2 and
3 h; no signs of toxicity
after 3 h
>9.59 g/kg bw (>10 mL/kg)
No mortality and no signs of
toxicity.
32,35
32
34
33
3 and 60 g/kg bw by gavage
>6 g/kg
32
10 mL/kg by gavage
>5 g/kg
No mortality and no signs of
toxicity.
>3.2 g/kg
32
9
29
29
>2 g/kg
No mortality and no signs of
toxicity.
>20 mL/kg no mortality
>2.0 mL/kg
No signs of toxicity; no gross
pathology
30
31
Reference
29
56

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