IJT - CIR - February 2024 - 110S

110S
International Journal of Toxicology 43(Supplement 1)
Table 7. (continued)
Test Article
Animals/
Group Vehicle
triethylhexyl trimellitate Crj:CD:SD
rats, 12M/
12F
corn
oil
Dose/
Concentration
0, 100, 300,or
1000 mg/kg/
day
Procedure
Males were dosed by gavage
for 46days, starting
14days prior to mating,
and females were dosed
14days prior to mating
through LD 3
Results
No effects on appearance,
body wt, feed
consumption, gross
pathology, reproductive
organ wts; no
microscopic effects in the
kidneys; number of
spermatocytes and
spermatids was slightly
reduced in 2/12 and 11/12
males of the mid- and
high-dose groups,
respectively, and
moderately decreased in
1 high-dose male
NOELs for reproductive
and developmental effects
were 100 mg/kg/day for
males and 1000 mg/kg/day
for females and offspring
triethylhexyl trimellitate 20 gravid
SpragueDawley
rats
(main
study)
corn
oil
0, 100, 500, or
1050 mg/kg
bw/day
Dams were dosed by gavage
on GD 6-19, and recovery
dams were dosed on GD
6 through LD 20
No treatment-related signs
of maternal toxicity, no
effects on fetal body wts
or litter viability, no
teratogenic effects, and
no effects upon sexual
maturation or
development of the
reproductive tract in
male or female pups; an
increase in the number of
fetuses with displaced
testes was in the high
dose group, however the
values were within
historical control ranges;
slight but statistically
significant increase in the
number of offspring with
retained areolar regions
in the high-dose group at
PND 13, but not PND 18
- this effect was not
considered
toxicologically significant.
15 recovery
animals
(control
and highdose)
NOAELs
were 1050 mg/kg
bw/day for maternal and
developmental toxicity,
and 500 mg/kg bw/ day for
postnatal development
(continued)
32
Reference
32

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