IJT - CIR - February 2024 - 30S

CIR Supplement Manuscript
Safety Assessment ofAlkyl Sultaines as Used in
Cosmetics
Christina L. Burnett*, Wilma F. Bergfeld**, Donald V. Belsito**,
Ronald A. Hill***, Curtis D. Klaassen**, Daniel C. Liebler***,
James G. Marks Jr***, Ronald C. Shank***, Thomas J. Slaga**,
Paul W. Snyder**, Monice Fiume†, and Bart Heldreth‡
Abstract
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 13 alkyl sultaines, which are most frequently
reported to function in cosmetics as antistatic agents, surfactants, and skin and hair conditioning agents. The Panel reviewed the
available data to determine the safety of these ingredients. The Panel noted gaps in the available safety data for some of the alkyl
sultaines in this safety assessment; the available data on some of the ingredients are sufficient, however, and can be read across to
support the safety of other members of the group. The Panel concluded that these alkyl sultaines are safe in cosmetics in the
present practices of use and concentration described in this safety assessment.
Keywords
Cosmetics, Safety, Capryl Sultaine, Cetyl/Lauryl/Myristyl Hydroxysultaine, Coco-Hydroxysultaine, Coco-Sultaine, Lauryl
Hydroxysultaine, Lauryl Sultaine, Myristyl Sultaine, Cocamidopropyl Hydroxysultaine, Erucamidopropyl Hydroxysultaine,
Lauramidopropyl Hydroxysultaine, Myristamidopropyl Hydroxysultaine, Oleamidopropyl Hydroxysultaine,
Tallowamidopropyl Hydroxysultaine
Introduction
The alkyl sultaines reviewed in this safety assessment are
reported to function as antistatic agents, surfactants, and skin
and hair conditioning agents in cosmetics, as described by the
web-based International Cosmetic Ingredient Dictionary and
Handbook(wINCI; Dictionary; Table 1).1 This report assesses
the safety as used in cosmetics of the following 13 alkyl
sultaine ingredients:
Capryl Sultaine
Cetyl/Lauryl/Myristyl
Hydroxysultaine
Coco-Hydroxysultaine
Coco-Sultaine
Lauryl Hydroxysultaine
Lauryl Sultaine
Cocamidopropyl
Hydroxysultaine
Erucamidopropyl
Hydroxysultaine
Lauramidopropyl
Hydroxysultaine
Myristamidopropyl
Hydroxysultaine
Oleamidopropyl
Hydroxysultaine
Tallowamidopropyl
Hydroxysultaine
Myristyl Sultaine
The sultaines are structurally related to betaines and are
sometimes referred to as sulfobetaines. Each of the
ingredients named in this report is a sulfopropyl quaternary
ammonium salt. The structures of the alkyl sultaines are
relatively similar, and certain toxicological data for one
ingredient may be informative about the toxicity of one or
more of the other ingredients in this report. The Panel has
previously reviewed the safety of Cocamidopropyl Betaine
and related aminopropyl betaines, and concluded that those
ingredients are " safe in cosmetics as long as they are formulated
to be non-sensitizing, which may be based on a
quantitative risk assessment (QRA). " 2 That caveat was included
in the conclusion due, in part, to data indicating
sensitization potential of the impurity 3,3-dimethylaminopropylamine
(DMAPA), which may exist in final formulations.
The aminopropyl betaines are zwitterionic and
*Cosmetic Ingredient Review Senior Scientific Analyst/Writer
**Expert Panel for Cosmetic Ingredient Safety Member
***Expert Panel for Cosmetic Ingredient Safety Former Member
†Cosmetic Ingredient Review Senior Director
‡Cosmetic Ingredient Review Executive Director
Corresponding Author:
Bart Heldreth, Executive Director, Cosmetic Ingredient Review, 1620 L
Street, NW, Suite 1200, Washington, DC 20036, USA.
Email: cirinfo@cir-safety.org
International Journal of Toxicology
2024, Vol. 43(Supplement 1) 30S-49S
© The Author(s) 2023
Article reuse guidelines:
sagepub.com/journals-permissions
DOI: 10.1177/10915818231221791
journals.sagepub.com/home/ijt
https://us.sagepub.com/en-us/journals-permissions https://doi.org/10.1177/10915818231221791 https://journals.sagepub.com/home/ijt

IJT - CIR - February 2024

Table of Contents for the Digital Edition of IJT - CIR - February 2024

Contents
IJT - CIR - February 2024 - Cover1
IJT - CIR - February 2024 - Cover2
IJT - CIR - February 2024 - 1S
IJT - CIR - February 2024 - 2S
IJT - CIR - February 2024 - Contents
IJT - CIR - February 2024 - 4S
IJT - CIR - February 2024 - 5S
IJT - CIR - February 2024 - 6S
IJT - CIR - February 2024 - 7S
IJT - CIR - February 2024 - 8S
IJT - CIR - February 2024 - 9S
IJT - CIR - February 2024 - 10S
IJT - CIR - February 2024 - 11S
IJT - CIR - February 2024 - 12S
IJT - CIR - February 2024 - 13S
IJT - CIR - February 2024 - 14S
IJT - CIR - February 2024 - 15S
IJT - CIR - February 2024 - 16S
IJT - CIR - February 2024 - 17S
IJT - CIR - February 2024 - 18S
IJT - CIR - February 2024 - 19S
IJT - CIR - February 2024 - 20S
IJT - CIR - February 2024 - 21S
IJT - CIR - February 2024 - 22S
IJT - CIR - February 2024 - 23S
IJT - CIR - February 2024 - 24S
IJT - CIR - February 2024 - 25S
IJT - CIR - February 2024 - 26S
IJT - CIR - February 2024 - 27S
IJT - CIR - February 2024 - 28S
IJT - CIR - February 2024 - 29S
IJT - CIR - February 2024 - 30S
IJT - CIR - February 2024 - 31S
IJT - CIR - February 2024 - 32S
IJT - CIR - February 2024 - 33S
IJT - CIR - February 2024 - 34S
IJT - CIR - February 2024 - 35S
IJT - CIR - February 2024 - 36S
IJT - CIR - February 2024 - 37S
IJT - CIR - February 2024 - 38S
IJT - CIR - February 2024 - 39S
IJT - CIR - February 2024 - 40S
IJT - CIR - February 2024 - 41S
IJT - CIR - February 2024 - 42S
IJT - CIR - February 2024 - 43S
IJT - CIR - February 2024 - 44S
IJT - CIR - February 2024 - 45S
IJT - CIR - February 2024 - 46S
IJT - CIR - February 2024 - 47S
IJT - CIR - February 2024 - 48S
IJT - CIR - February 2024 - 49S
IJT - CIR - February 2024 - 50S
IJT - CIR - February 2024 - 51S
IJT - CIR - February 2024 - 52S
IJT - CIR - February 2024 - 53S
IJT - CIR - February 2024 - 54S
IJT - CIR - February 2024 - 55S
IJT - CIR - February 2024 - 56S
IJT - CIR - February 2024 - 57S
IJT - CIR - February 2024 - 58S
IJT - CIR - February 2024 - 59S
IJT - CIR - February 2024 - 60S
IJT - CIR - February 2024 - 61S
IJT - CIR - February 2024 - 62S
IJT - CIR - February 2024 - 63S
IJT - CIR - February 2024 - 64S
IJT - CIR - February 2024 - 65S
IJT - CIR - February 2024 - 66S
IJT - CIR - February 2024 - 67S
IJT - CIR - February 2024 - 68S
IJT - CIR - February 2024 - 69S
IJT - CIR - February 2024 - 70S
IJT - CIR - February 2024 - 71S
IJT - CIR - February 2024 - 72S
IJT - CIR - February 2024 - 73S
IJT - CIR - February 2024 - 74S
IJT - CIR - February 2024 - 75S
IJT - CIR - February 2024 - 76S
IJT - CIR - February 2024 - 77S
IJT - CIR - February 2024 - 78S
IJT - CIR - February 2024 - 79S
IJT - CIR - February 2024 - 80S
IJT - CIR - February 2024 - 81S
IJT - CIR - February 2024 - 82S
IJT - CIR - February 2024 - 83S
IJT - CIR - February 2024 - 84S
IJT - CIR - February 2024 - 85S
IJT - CIR - February 2024 - 86S
IJT - CIR - February 2024 - 87S
IJT - CIR - February 2024 - 88S
IJT - CIR - February 2024 - 89S
IJT - CIR - February 2024 - 90S
IJT - CIR - February 2024 - 91S
IJT - CIR - February 2024 - 92S
IJT - CIR - February 2024 - 93S
IJT - CIR - February 2024 - 94S
IJT - CIR - February 2024 - 95S
IJT - CIR - February 2024 - 96S
IJT - CIR - February 2024 - 97S
IJT - CIR - February 2024 - 98S
IJT - CIR - February 2024 - 99S
IJT - CIR - February 2024 - 100S
IJT - CIR - February 2024 - 101S
IJT - CIR - February 2024 - 102S
IJT - CIR - February 2024 - 103S
IJT - CIR - February 2024 - 104S
IJT - CIR - February 2024 - 105S
IJT - CIR - February 2024 - 106S
IJT - CIR - February 2024 - 107S
IJT - CIR - February 2024 - 108S
IJT - CIR - February 2024 - 109S
IJT - CIR - February 2024 - 110S
IJT - CIR - February 2024 - 111S
IJT - CIR - February 2024 - 112S
IJT - CIR - February 2024 - 113S
IJT - CIR - February 2024 - 114S
IJT - CIR - February 2024 - 115S
IJT - CIR - February 2024 - 116S
IJT - CIR - February 2024 - 117S
IJT - CIR - February 2024 - 118S
IJT - CIR - February 2024 - Cover3
IJT - CIR - February 2024 - Cover4
https://www.nxtbookmedia.com