IJT - CIR - February 2024 - 38S

38S
International Journal of Toxicology 43(Supplement 1)
Table 2. Physical and Chemical Properties.
Property
Cocamidopropyl Hydroxysultaine
Physical form
Density (g/mL @ 20°C)
Vapor pressure (mmHg @ 25°C)
Boiling point (°C)
Water solubility (g/l @ 20°C)
Log Po/w (@ 25°C)
Capryl Sultaine
Physical form
Molecular weight (Da)
Water solubility
Log Po/w (@ 25°C)
Erucamidopropyl Hydroxysultaine
Molecular weight (Da)
Log Po/w (@ 25°C)
Lauramidopropyl Hydroxysultaine
Physical form
Molecular weight (Da)
Density (g/mL @ 20°C)
Vapor pressure (mmHg @ 20°C)
Melting point (°C)
Boiling point (°C)
Water solubility (g/l @ 20°C, pH 8.56 -8.64)
log Po/w (@ 25°C)
Lauryl Hydroxysultaine
Physical form
Molecular weight (Da)
Density (g/mL @ 25°C)
Vapor pressure (mmHg @ 25°C)
Melting point (°C)
Boiling point (°C)
Lauryl Sultaine
Molecular weight (Da)
log Po/w (@ 22°C)
Myristamidopropyl Hydroxysultaine
Molecular weight (Da)
Log Po/w (@ 25°C)
Myristyl Sultaine
Molecular weight (Da)
Log Po/w (@ 25°C)
Oleamidopropyl Hydroxysultaine
Molecular weight (Da)
Log Po/w (@ 25°C)
5% in leave on cosmetic products and up to 10% in rinse off
cosmetic products and cleaning products], the notified chemical
is not considered to pose an unacceptable risk to public health. " 6
Toxicokinetics
No published toxicokinetics studies on alkyl sultaines were
discovered and no unpublished data were submitted.
Value
Reference
liquid
1.22
1.725 x 10-10
280.5
556
2.1
white powder
307.49
10% in water gives a clear solution
1.26 (estimated)
560.88
4.36 (estimated)
yellow aqueous solution
422.63
1.304 - 1.306
1.725 x 10-10
55.0 (mean)
311.6 (mean)
> 500
2.1
colorless to light yellow liquid
351.55
1.108
8.25 x 10-18 (estimated)
272 (estimated)
627 (estimated)
335.55
1.65
450.68
.64 (estimated)
363.60
3.22 (estimated)
504.77
2.39 (estimated)
5
5
5
5
5
5
16
38
16
39
38
39
4
38
4
4
4
4
4
4
6
38
6
6
6
6
38
6
38
39
38
39
38
39
Toxicological Studies
Acute Toxicity Studies
Dermal and oral acute toxicity studies for Cocamidopropyl
Hydroxysultaine and Lauryl Hydroxysultaine are summarized
in Table 5. In an acute dermal study performed in rats, 36.2%
Cocamidopropyl Hydroxysultaine in solution has an LD50 >
2000 mg active ingredient/kg bw.5 In acute oral studies, the

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