IJT - CIR - February 2024 - 39S

Burnett et al.
39S
Table 3. Frequency (2018) and Concentration of Use (2017) According to Duration and Type of Exposure for Alkyl Sultaines.19,20.
#of
Uses
Max Conc of
Use (%)
Totalsa
Duration of use
Leave-on
Rinse off
Diluted for (bath)
use
Exposure type
Eye area
Incidental
ingestion
Incidental
inhalationspray
Incidental
inhalationpowder
Dermal
contact
Deodorant
(underarm)
Hair - noncoloring
Mucous
membrane
Baby
products NR NR
3
2.2
NR NR NR NR NR NR
NR = Not reported.
aBecause each ingredient may be used in cosmetics with multiple exposure types, the sum of all exposure types may not equal the sum of total uses.
bIt is possible these products may be sprays, but it is not specified whether the reported uses are sprays.
cNot specified whether a powder or a spray, so this information is captured for both categories of incidental inhalation.
dIt is possible these products may be powders, but it is not specified whether the reported uses are powders.
Table 4. Ingredients Not Reported in Use.19,20
Cetyl/Lauryl/Myristyl Hydroxysultaine
Coco-Hydroxysultaine
Coco-Sultaine
Lauramidopropyl Hydroxysultaine
Myristamidopropyl Hydroxysultaine
Myristyl Sultaine
Oleamidopropyl Hydroxysultaine
Tallowamidopropyl Hydroxysultaine
LD50 for 42% Cocamidopropyl Hydroxysultaine was
2950 mg active ingredient/kg bw in rats and 3150 mg active
ingredient/kg bw in mice.5 The LD50 for 28% to 32% Lauryl
Hydroxysultaine was >560-640 mg/kg bw active ingredient in
rats.6
Short-Term Toxicity Studies
Cocamidopropyl Hydroxysultaine. The short-term toxicity effects
of 36.2% Cocamidopropyl Hydroxysultaine in aqueous
solution were assessed in accordance with the Organization
for Economic Co-operation and Development (OECD) test
guideline (TG) 422 (combined repeated dose toxicity study
with the reproduction/developmental toxicity screening test)
using groups of10 male and 10 female Sprague-Dawley rats.5
The test material was administered daily by gavage before
mating, during mating, and in females, through day 5 postpartum,
at dose levels of30, 100, or 300 mg/kg/day (exposure
duration was 5 weeks in males and 6 to 8 weeks in females).
An additional group of 10 males and 10 females received the
vehicle control, i.e., drinking water, under the same experimental
conditions at a dosing volume of 5 mL/kg/day. The
animals were observed daily for clinical signs and mortality.
Detailed clinical observations were conducted weekly. Body
2
.25
NR NR
Hair-coloring NR NR
Nail
180
98
2
.1-11.5
1
NR
.05-5NR NR
1.5
.13-6.8
2
2
4.5
2
NR
NR NR NR NR NR NR NR NR NR NR
5 NR NR
NR NR NR .013 NR NR
NR NR NR NR NR NR NR NR NR NR
NR NR 119
1
NR NR NR
2
NR
NR .25d
3c
2.5d
NR NR NR NR NR NR
Capryl Sultaine
2
2
NR
#of
Uses
Max Conc of
Use (%)
Cocamidopropyl
Hydroxysultaine
.25
.25
.25
NR NR
280 .05-11.5
15
242
23
.1-11.5
.97-6
#of
Uses
Max Conc of
Use (%)
Erucamidopropyl
Hydroxysultaine
1
1
NR
NR
#of
Uses
Max Conc of
Use (%)
Lauryl
Hydroxysultaine
4
Lauryl Sultaine
.013-52 NR
.05-2.5 NR NR NR NR NR NR
4
NR
NRNRNR
.013-52 NR
NRNR
NR NR NR NR NR NR NR NR NR NR
NR NR NR NR NR NR NR NR NR NR
NR .25b
10b;3c .05; .18-.58b NR NR NR NR NR NR
#of
Uses
Max Conc of
Use (%)

IJT - CIR - February 2024

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