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48S
International Journal of Toxicology 43(Supplement 1)
Conclusion
The Expert Panel for Cosmetic Ingredient Safety concluded
that the following 13 alkyl sultaines are safe in cosmetics in
the present practices ofuse and concentration described in this
safety assessment.
Capryl Sultaine
Cetyl/Lauryl/Myristyl
Hydroxysultaine*
Coco-Hydroxysultaine*
Coco-Sultaine*
Lauryl Hydroxysultaine
Lauryl Sultaine
Cocamidopropyl
Hydroxysultaine*
Erucamidopropyl
Hydroxysultaine
Lauramidopropyl
Hydroxysultaine*
Myristamidopropyl
Hydroxysultaine*
Oleamidopropyl
Hydroxysultaine*
Tallowamidopropyl
Hydroxysultaine*
Myristyl Sultaine*
*Not reported to be in current use. Were ingredients in this
group not in current use to be used in the future, the expectation
is that they would be used inproduct categories and
at concentrations comparable to others in this group.
Author Contributions
The articles in this supplement were sponsored by the Cosmetic
Ingredient Review.
Author's Note
Unpublished sources cited in this report are available from the Director,
Cosmetic Ingredient Review, 1620 L Street, NW, Suite 1200,
Washington, DC 20036, USA.
Declaration of Conflicting Interests
The author(s) declared the following potential conflicts of interest
with respect to the research, authorship, and/or publication of this
article: The articles in this supplement were sponsored by the
Cosmetic Ingredient Review.
Funding
The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication ofthis article: The articles
in this supplement were sponsored by the Cosmetic Ingredient Review.
The Cosmetic Ingredient Review is financially supported by the
Personal Care Products Council.
References
1. Nikitakis J, Lange B. wINCI: International Cosmetic Ingredient
Dictionary and Handbook. Washington, DC; 2017. Last Updated.
https://webdictionary.personalcarecouncil.org/jsp/Home.
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2. Burnett CL, Bergfeld WF, Belsito DV, et al. Final report of the
Cosmetic Ingredient Review Expert Panel on the safety
assessment of cocamidopropyl betaine (CAPB). Int J Toxicol.
2012;31(Suppl 1):77S-111S.
3. Burnett CL, Bergfeld WF, Belsito DV, et al. Safety assessment of
alkyl betaines as used in cosmetics. Int J Toxicol. 2018;37(Suppl.
1):28S-S46.
4. European Chemicals Agency. (2-Hydroxy-3-sulphopropyl)
dimethyl[3-[(1-oxododecyl)amino]propyl]ammonium hydroxide.
2017. Last Updated. https://echa.europa.eu/https://echa.
europa.eu/. Date Accessed 6-22-2017
5. European Chemicals Agency. 1-Propanaminium, N-(3aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-,
N-(C8-18(even
numbered) acyl) derivs., hydroxides, inner salts. 2017. Last Updated.
https://echa.europa.eu/https://echa.europa.eu/. Date Accessed
6-22-2017
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Inner Salt (INCI: Lauryl Hydroxysultaine).
2011. Date Accessed 6-27-2017.Report No. STD/1363.
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Unpublished data submitted by Personal Care
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8. Protameen Chemicals Inc. Method of Manufacture and Composition
ofCocamidopropyl Hydroxysultaine. Unpublished data
submitted by Personal Care Products Council; 2017.
9. Anonymous. Method of Manufacture Colateric CBS (Cocamidopropyl
Hydroxysultaine). Unpublished data submitted by
Personal Care Products Council; 2017.
10. Anonymous. Product Information Cocamidopropyl Hydroxysultaine:
Process Diagram. Unpublished data submitted by
Personal Care Products Council; 2017.
11. Anonymous. Method of Manufacture Colateric LHS (Lauryl
Hydroxysultaine). Unpublished data submitted by Personal Care
Products Council; 2017.
12. Shank RC, Magee PN. Toxicity and carcinogenicity ofN-nitroso
compounds. Chapter: 1. In: Mycotoxins and N-Nitroso Compounds:
Environmental Risks. Boca Raton, FL: CRC Press, Inc.;
1981:185-217.
13. Zamora D, Alcala M, Blanco M. Determination of trace impurities
in cosmetic intermediates by ion mobility spectrometry.
Anal Chim Acta. 2011;708:69-74.
14. Minguet M, Subirats N, Castan P, Sakai T. Behenamidopropyl
dimethylamine: unique behaviour in solution and in hair care
formulations. Int J Cosmet Sci. 2010;32:246-257.
15. Littler C. Letter from Curt Littler, MD Concerning Cosmetic
Products Containing 0.25% Capryl Sultaine. Unpublished data
submitted by Personal Care Products Council; 2017.
16. Glentham Life Sciences. Product Specification; 2017. Last
Updated https://www.glentham.com/en/products/product/
GE2259/specification/. Date Accessed 12-11-2017.
17. Personal Care Products Council. 8-24-2017. Cocamidopropyl
Hydroxysultaine and Lauramidopropyl Hydroxysultaine. Unpublished
data submitted by Personal Care Products Council.
18. Personal Care Products Council. 9-19-2017. Cocamidopropyl
Hydroxysultaine. Unpublished data submitted by Personal Care
Products Council.
https://echa.europa.eu/ https://echa.europa.eu/ https://echa.europa.eu/ https://echa.europa.eu/https://echa.europa.eu/ https://echa.europa.eu/ https://echa.europa.eu/ https://www.glentham.com/en/products/product/GE2259/specification/ https://www.glentham.com/en/products/product/GE2259/specification/ https://webdictionary.personalcarecouncil.org/jsp/Home.jsp https://webdictionary.personalcarecouncil.org/jsp/Home.jsp

IJT - CIR - February 2024

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