IJT - CIR - February 2024 - 50S

CIR Supplement Manuscript
Safety Assessment of Adenosine as Used in
Cosmetics
Priya Cherian*, Wilma F. Bergfeld**, Donald V. Belsito**,
Ronald A. Hill***, Curtis D. Klaassen**, Daniel C. Liebler***,
James G. Marks Jr***, Ronald C. Shank***, Thomas J. Slaga**,
Paul W. Snyder**, Monice Fiume†, and Bart Heldreth††
Abstract
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Adenosine, Adenosine Phosphate, Adenosine
Triphosphate, Disodium Adenosine Phosphate, and Disodium Adenosine Triphosphate. These ingredients are reported to
function in cosmetics as skin-conditioning agents - miscellaneous. The Panel considered the available data and concluded that
the five adenosine ingredients reviewed in this report are safe in cosmetics in the present practices of use and concentration
described in this safety assessment.
Keywords
Adenosine, Adenosine Phosphate, Adenosine Triphosphate, Disodium Adenosine Phosphate, and Disodium Adenosine
Triphosphate
Introduction
This is a safety assessment of Adenosine, Adenosine Phosphate,
Adenosine Triphosphate, Disodium Adenosine Phosphate,
and Disodium Adenosine Triphosphate as used in
cosmetic formulations. According to the web-based International
Cosmetic Ingredient Dictionary and Handbook
(wINCI; Dictionary), these ingredients are reported to function
in cosmetics as skin-conditioning agents - miscellaneous.1
(Table 1) These adenosine ingredients are being
reviewed together due to their structural similarities.
This safety assessment includes relevant published and unpublished
data that are available for each endpoint that is evaluated.
Published data are identified by conducting an exhaustive search of
the world's literature. A listing of the search engines and websites
that are used and the sources that are typically explored, as well as
the endpoints that the Panel typically evaluates, is provided on the
Cosmetic Ingredient Review (CIR) website (https://www.cir-safety.
org/supplementaldoc/preliminary-search-engines-and-websites;
https://www.cir-safety.org/supplementaldoc/cir-report-formatoutline).
Unpublished data are provided by the cosmetics industry,
as well as by other interested parties.
Some of the data included in this safety assessment were
found on the European Chemicals Agency (ECHA) website.2
These summaries are available on the ECHA website, and
when deemed appropriate, information from these summaries
have been included in this report.
Chemistry
Definition and Structure
The definitions and structures ofthe ingredients included in this
review are provided in Table 1. All of these ingredients share
Adenosine (CAS No. 58-61-7; Molecular Weight = 267.25 g/
mol; log Kow =1.05; Figure 1) as the core structure.
Adenosine Triphosphate (ATP; CAS No. 56-65-5; MolecularWeight
= 507.18 g/mol; log Kow =3.61) is composed
of a purine nucleoside esterified with a triphosphate.3
Adenosine Triphosphate is a ubiquitous organophosphate
that connects anabolism and catabolism, but also fuels processes
such as motile contraction, phosphorylations, and active
transport.4 Both Adenosine and Adenosine Phosphate
(AMP; CAS No. 61-19-8; Molecular Weight = 507.18 g/mol;
log Kow =3.1) are formed when Adenosine Triphosphate is
*Cosmetic Ingredient Review Senior Scientific Analyst/Writer
**Expert Panel for Cosmetic Ingredient Safety Member
***Expert Panel for Cosmetic Ingredient Safety Former Member
†Cosmetic Ingredient Review Senior Director
††Cosmetic Ingredient Review Executive Director
Corresponding Author:
Bart Heldreth, Executive Director, Cosmetic Ingredient Review, 1620 L
Street, NW, Suite 1200, Washington, DC 20036, USA.
Email: cirinfo@cir-safety.org
International Journal of Toxicology
2024, Vol. 43(Supplement 1) 50S-63S
© The Author(s) 2023
Article reuse guidelines:
sagepub.com/journals-permissions
DOI: 10.1177/10915818231221790
journals.sagepub.com/home/ijt
https://us.sagepub.com/en-us/journals-permissions https://doi.org/10.1177/10915818231221790 https://journals.sagepub.com/home/ijt https://www.cir-safety.org/supplementaldoc/preliminary-search-engines-and-websites https://www.cir-safety.org/supplementaldoc/preliminary-search-engines-and-websites https://www.cir-safety.org/supplementaldoc/cir-report-format-outline https://www.cir-safety.org/supplementaldoc/cir-report-format-outline

IJT - CIR - February 2024

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Contents
IJT - CIR - February 2024 - Cover1
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IJT - CIR - February 2024 - Contents
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IJT - CIR - February 2024 - Cover3
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