IJT - CIR - February 2024 - 52S

52S
International Journal of Toxicology 43(Supplement 1)
Table 1. (continued)
Ingredient
Disodium Adenosine
Phosphate (4578-31-8)
Definition
Function
Disodium Adenosine Phosphate is the disodium salt of Adenosine Phosphate
Skin-conditioning
agents - Miscellaneous
Disodium Adenosine
Triphosphate (987-65-5)
Disodium Adenosine Triphosphate is the disodium salt of Adenosine Triphosphate Skin-conditioning
agents - Miscellaneous
consumed in metabolic processes. Adenosine, a ribonucleoside
comprising adenine and ribose, exerts pleiotropic functions
throughout the body, primarily by interaction with Gprotein
coupled receptors.5 Adenosine Phosphate is an ester of
phosphoric acid and Adenosine. Like Adenosine Triphosphate,
Adenosine Phosphate plays an important role in many
cellular metabolic processes, and is an intermediate in the
synthesis of nucleic acids.
Chemical Properties
The ingredients named in this report (with reported properties)
are solids at room temperature and are soluble in water.
Available information on the chemical properties are presented
in Table 2.
Method of Manufacture
These methods are general to the production ofAdenosine and
Adenosine Triphosphate. No methods specific to cosmetic
ingredient manufacture were found in the literature or submitted
as unpublished data.
Adenosine. The main methods of manufacturing Adenosine
include chemical synthesis, RNA degradation, and microbial
fermentation.6 Bacillus subtilis is commonly used as it is a safe
and stable producer of purine nucleosides.

IJT - CIR - February 2024

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