IJT - CIR - February 2024 - 54S

54S
International Journal of Toxicology 43(Supplement 1)
Use
Cosmetic
The safety of the cosmetic ingredients addressed in this assessment
is evaluated based on data received from the US Food
and Drug Administration (FDA) and the cosmetics industry on
the expected use of these ingredients in cosmetics. Use
frequencies of individual ingredients in cosmetics are collected
from manufacturers and reported by cosmetic product
category in the FDA Voluntary Cosmetic Registration Program
(VCRP) database. Use concentration data are submitted
by the cosmetic industry in response to a survey, conducted
by the Personal Care Products Council (Council), of maximum
reported use concentrations by product category.
Table 3. Frequency (2020) and Concentration (2018) of Use.11,12
# of Uses Max Conc of Use (%) # of Uses Max Conc of Use (%) # of Uses Max Conc of Use (%)
Adenosine
Totalsa
Duration of use
Leave-on
Rinse-off
Diluted for (bath) use
Exposure type
Eye area
Incidental ingestion
Dermal contact
Deodorant (underarm)
Hair - non-coloring
Hair-coloring
Nail
Mucous membrane
Baby products
Totalsa
Duration of use
Leave-on
Rinse off
Diluted for (bath) use
Exposure type
Eye area
Incidental ingestion
Incidental inhalation-spray
Incidental inhalation-powder
Dermal contact
Deodorant (underarm)
Hair - non-coloring
Hair-coloring
Nail
Mucous membrane
Baby products
905
868
37
NR
87
2
Incidental inhalation-spray 326b; 301c
Incidental inhalation-powder 326b
897
NR
5
NR
NR
3
NR
.04-1
.04-1
.041
NR
.041
NR
.04-.041
.1; .04-1d
.04-1
NR
NR
NR
NR
NR
NR
96
Adenosine Phosphate
.001-.5
81
15
NR
12
NR
1; 10b;54c
10b
68
NR
27
NR
NR
NR
NR
116
100
16
NR
11
NR
41b;43c
41b
116
NR
NR
NR
NR
3
NR
.0048-.5
.001-.04
NR
.04-.5
NR
.04; .11c
.058d
.001-.058
NR
.0095-.11
NR
NR
NR
NR
42
35
7
NR
2
NR
8b;17c
8b
35
NR
1
NR
6
NR
NR
Disodium adenosine triphosphate
.003-.1
.003-.1
.003-.005
NR
.003
NR
NR
.003d
.003-.1
NR
.005
NR
NR
NR
NR
NR - no reported use.
aBecause each ingredient may be used in cosmetics with multiple exposure types, the sum of all exposure types may not equal the sum of total uses.
bNot specified whether a spray or a powder, but it is possible the use can be as a spray or a powder, therefore the information is captured in both categories.
cIt is possible these products are sprays, but it is not specified whether the reported uses are sprays.
dIt is possible these products are powders, but it is not specified whether the reported uses are powders.
Adenosine Triphosphate
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR

IJT - CIR - February 2024

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Contents
IJT - CIR - February 2024 - Cover1
IJT - CIR - February 2024 - Cover2
IJT - CIR - February 2024 - 1S
IJT - CIR - February 2024 - 2S
IJT - CIR - February 2024 - Contents
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IJT - CIR - February 2024 - 54S
IJT - CIR - February 2024 - 55S
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IJT - CIR - February 2024 - 101S
IJT - CIR - February 2024 - 102S
IJT - CIR - February 2024 - 103S
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IJT - CIR - February 2024 - 105S
IJT - CIR - February 2024 - 106S
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IJT - CIR - February 2024 - 109S
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IJT - CIR - February 2024 - 115S
IJT - CIR - February 2024 - 116S
IJT - CIR - February 2024 - 117S
IJT - CIR - February 2024 - 118S
IJT - CIR - February 2024 - Cover3
IJT - CIR - February 2024 - Cover4
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