IJT - CIR - February 2024 - 65S

Burnett et al.
65S
Ginkgo biloba-derived ingredients in cosmetics, with specific
focus on dermal application when available.
Because often in the published literature the information
provided is not sufficient to determine how well the tested
substance represents the cosmetic ingredient, the taxonomic
name is used unless it is clear that the test substance is similar
to a cosmetic ingredient. However, in the case of data on the
extract ofGinkgo biloba leaves, the abbreviation GBE will be
used, unless the data specifically are related to the cosmetic
use of Ginkgo Biloba Leaf Extract.
Botanicals, such as Ginkgo biloba-derived ingredients,
may contain hundreds of constituents, some of which may
have the potential to cause toxic effects. In this assessment, the
Panel is reviewing the potential toxicity ofeach ofthe Ginkgo
biloba-derived ingredients as a whole, complex mixture. The
Panel is not reviewing the potential toxicity of the individual
constituents, except wherein such constituents are also ingredients
under review.
This safety assessment includes relevant published and
unpublished data for each endpoint that is evaluated. Published
data are identified by conducting an exhaustive search
of the world's literature. A listing of the search engines and
websites that are used and the sources that are typically
Definition and Structure
explored, as well as the endpoints that the Panel typically
evaluates, is provided on the CIR website (https://www.cirsafety.org/supplementaldoc/preliminary-search-engines-andwebsites;
https://www.cir-safety.org/supplementaldoc/cirreport-format-outline).
Unpublished data are provided by the
cosmetics industry, as well as by other interested parties.
Chemistry
Definition and Plant Identification
The definitions and functions of the Ginkgo biloba-derived
ingredients included in this report are provided in Table 1.
The raw materials for the ingredients in this report are
obtained from the deciduous tree, Ginkgo biloba,which has
fan-shaped leaves that turn golden yellow in autumn. These
trees can grow to 40 m (∼131 ft) tall.2 The female trees bear
offensive-smelling, inedible fruit that contain a single thinshelled
semi-edible nut. Ginkgo trees are planted widely as
ornamental trees via cultivation. Few naturally-occurring
specimens grow in Zhejiang province China. Trees grown
commercially for the leaves are found in China, France, and
in the US.
Table 1. Definitions and Functions of the Ingredients in this Safety Assessment.1
Ingredient/CAS No.
Ginkgo Biloba Leaf Extract
90045-36-6
Ginkgo Biflavones
Ginkgo Biloba Leaf
90045-36-6
Ginkgo Biloba Leaf Cell
Extract
90045-36-6
Ginkgo Biloba Leaf Powder
90045-36-6
Ginkgo Biloba Leaf Water
90045-36-6
Ginkgo Biloba Meristem
Cell
Ginkgo Biloba Nut Extract
90045-36-6
Ginkgo Biloba Root
Extract 90045-36-6
Ginkgo Leaf Terpenoids
107438-79-9
15291-75-5
15291-76-6
15291-77-7
33570-04-6
Ginkgo biloba leaf powder is the powder obtained from the
dried, ground leaves of Ginkgo biloba.
Ginkgo biloba leaf water is the aqueous solution of the steam
distillate obtained from the leaves of Ginkgo biloba.
Ginkgo biloba meristem cell are the cultured meristem cells
isolated from Ginkgo biloba.
Ginkgo biloba nut extract is the extract of the seeds of Ginkgo
biloba.
Ginkgo biloba root extract is the extract of the roots of Ginkgo
biloba.
Ginkgo leaf terpenoids is a mixture of terpenoids isolated
from the leaves of Ginkgo biloba consisting chieflyof
ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J, and
bilobalide.
Skin-conditioning agent - misc
Fragrance ingredient; skin-conditioning agent -
misc
Antimicrobial agent; antioxidant; skinconditioning
agent - misc
Cosmetic astringent; hair conditioning agent; nail
conditioning agent; skin-conditioning agent -
misc
Skin-conditioning agent - misc
Antiacne agent; antifungal agent; antimicrobial
agent; antioxidant; external analgesics; hair
conditioning agent
Ginkgo biloba leaf extract is the extract of the leaf of Ginkgo
biloba.
Ginkgo biflavones is a mixture of biflavones derived from the
leaves of Ginkgo biloba. It consists predominantly of
sciadopitysin, bilobetin, ginkgetin, and isoginkgetin.
Ginkgo biloba leaf is the leaf of Ginkgo biloba.
Ginkgo biloba leaf cell extract is the extract of a culture of the
leaf cells of Ginkgo biloba.
Antioxidant
Skin-conditioning agent - misc
Flavoring agents; skin protectant
Function
Skin-conditioning agent - misc
https://www.cir-safety.org/supplementaldoc/preliminary-search-engines-and-websites https://www.cir-safety.org/supplementaldoc/preliminary-search-engines-and-websites https://www.cir-safety.org/supplementaldoc/preliminary-search-engines-and-websites https://www.cir-safety.org/supplementaldoc/cir-report-format-outline https://www.cir-safety.org/supplementaldoc/cir-report-format-outline

IJT - CIR - February 2024

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IJT - CIR - February 2024 - Cover3
IJT - CIR - February 2024 - Cover4
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