Medical Manufacturing & Outsourcing - Version A. April 2021 - 19

" Digitalization and 3D printing
have been transforming the design
and manufacture of complex medical
devices, surgery planning, medical
education, and care delivery. Even
though 3D printing technology has
been around for more than three
decades since the early 90s, it wasn't
until recently that people really began
to appreciate and trust it for end-use
fabrication. In this work, 3D printing
freed us from the manufacturing

constraints and enabled us to optimize
the design to suit the patient's needs.
More importantly, this work sets the
groundwork for future patient-specific,
end-use 3D-printed parts for prosthetic
needs,'' said principal investigator,
Subburaj Karupppasamy, an assistant
professor in SUTD's Engineering
Product Devel-opment pillar.
Trevor Binedell, principal prosthetist
at the Foot Care and Limb Design
Centre, TTSH, and Ph.D. student from

SUTD, adds, " The collaboration between
TTSH and SUTD has led to a great
outcome for this patient. User-design
and the digitalization techniques have
elevated the levels of patient-specific
care to create individual designs that
truly meet the needs of the user. This
process has the potential to improve
unique designs for many of our patients
and enhance their quality of lives. "
For more information, visit
www.sutd.edu.sg.

Handheld 3D Printers Treat Musculoskeletal Injuries
Scaffold materials adhere precisely to tissues surrounding an injury, eliminating the need
for suturing.
University of Connecticut, School of Dental Medicine, Farmington

B

iomedical engineers developed a
handheld 3D bioprinter that could
revolutionize the way musculoskeletal
surgical procedures are performed.
The bioprinter enables surgeons
to deposit scaffolds - or materials
to help support cellular and tissue

growth - directly into the defect
sites within weakened skeletal
muscles. The printer allows proper
filling of the cavity with fibrillar
scaffolds in which fibers resemble
the architecture of the native tissue.
The scaffolds from the bioprinter

The bioprinter enables surgeons to deposit scaffolds directly into the defect sites within weakened
skeletal muscles.

MEDICAL MANUFACTURING AND OUTSOURCING SPECIAL REPORT

adhere precisely to the surrounding
tissues of the injury and mimic the
properties of the existing tissue,
eliminating the need for any suturing.
Current methods for reconstructive
surgery have been largely inadequate
in treating volumetric muscle loss.
As a result, 3D printing technology
has emerged as a new solution to
help re-construct muscle. Existing 3D
bioprinting technology is not without
its problems. Implanting the hydrogelbased scaffolds successfully requires
a very specific biomaterial to be
printed that will adhere to the defect
site. While 3D-bioprinted scaffolds
mimicking skeletal muscles have been
created in vitro, they have not been
successfully used on an actual subject.
The new bioprinter prints gelatinbased hydrogels - known as
" bioink " - that have been proven to
be effective in adhering to defect sites
of mice with volumetric muscle loss
injury. The mice showed a significant
increase in muscle hypertrophy
following this therapy. In addition, the
system does not require sophisticated
imaging and printing systems.
For more information, contact
Kim Krieger at kim.krieger@
uconn.edu; 860-486-0361.

APRIL 2021 19


http://info.hotims.com/79412-1008

Medical Manufacturing & Outsourcing - Version A. April 2021

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