Medical Manufacturing & Outsourcing - Version A. April 2021 - 21

rat bones led to about three times
more blood vessel growth than
conventional scaffolding material.
The 3D-printed microcage
technology improves healing
by stimulating the right type of
cells to grow in the right place at
the right time. Different growth
factors can be placed inside each
block, enabling more precise
and quicker re-p air tissue.

The small devices are modular and
can be assembled to fit into almost
any space. When piecing together
block segments containing four
layers of four bricks by four bricks,
the researchers estimate more than
29,000 different configurations can
be created. They also envision that the
3D-printed technology could be used
to heal bones that have to be cut out
for cancer treatment, for spinal fusion

procedures, and to build up weakened
jaw bones ahead of a dental implant.
By changing the composition of the
3D-printed materials, it could also be
used to build or repair soft tissues.
With significantly more research, the
mod-ular microcage ap--proach could be
used to make organs for transplant.
For more information, contact
Franny White at 503-494-8231;
whitef@ohsu.edu.

Rapid 3D-Printing of Biomedical Parts
The structures' small size and porosity make them well-suited for building components
such as replacement joints.
Cornell University, Ithaca, New York

A

created a more porous
3D printing technique
structure, which is ideal for
was developed that
biomedical applications
creates cellular metallic
such as artificial joints
materials by smashing
for the knee or hip and
together powder particles
cranial/facial implants.
at supersonic speed.
Implants made with
This form of technology,
these porous structures,
known as cold spray,
when inserted in the body,
results in mechanically
the bone can grow inside
robust, porous structures
the pores and make a
that are 40% stronger
biological fixation. This
than similar materials
helps reduce the likelihood
made with conventional
of the implant loosening,
manufacturing processes.
This image shows cells adhering to a titanium alloy created by cold-spray 3D
eliminating the need
The structures' small
printing, which demon-strates the material's biocompatibility.
for revision surgeries
size and porosity make
that patients have to
them particularly
go through to remove the implant
of compressed gas to fire titanium
well-suited for building biomedical
because it is loose and causes pain.
alloy particles at a substrate. The
components like replacement joints.
While the process is technically
particles were between 45 and 106
Instead of using only heat as
termed cold spray, it did involve some
microns in diameter and traveled at
the input or the driving force for
heat treatment. Once the particles
roughly 600 meters per second, faster
bonding, the researchers used
collided and bonded together, the re-
than the speed of sound. Typically, in
plastic deformation to bond the
searchers heated the metal so the
cold spray printing, a particle would
powder particles together.
components would diffuse into each
accelerate in the sweet spot between
Additive manufacturing is not
other and settle like a homogeneous
its critical velocity - the speed at
without its challenges - foremost
material. The team focused on titanium
which it can form a dense solid - and
among them is that metallic
alloys and biomedical applications
its erosion velocity: when it crumbles
materials need to be heated at high
but the applicability of the process
too much to bond to anything.
temperatures that exceed their
could extend to any metallic material
Instead, the team used computational
melting point, which can cause
that can endure plastic deformation.
fluid dynamics to determine a speed
residual stress buildup, distortion, and
For more information, contact
just under the titanium alloy particle's
unwanted phase transformations.
Jeff Tyson at 607-793-5769;
critical velocity. When launched at
To eliminate these issues, the team
jeff.tyson@cornell.edu.
this slightly slower rate, the particles
developed a method using a nozzle
MEDICAL MANUFACTURING AND OUTSOURCING SPECIAL REPORT

APRIL 2021 21



Medical Manufacturing & Outsourcing - Version A. April 2021

Table of Contents for the Digital Edition of Medical Manufacturing & Outsourcing - Version A. April 2021

Medical Manufacturing & Outsourcing - Version A. April 2021 - Cov1
Medical Manufacturing & Outsourcing - Version A. April 2021 - Cov2
Medical Manufacturing & Outsourcing - Version A. April 2021 - 1
Medical Manufacturing & Outsourcing - Version A. April 2021 - 2
Medical Manufacturing & Outsourcing - Version A. April 2021 - 3
Medical Manufacturing & Outsourcing - Version A. April 2021 - 4
Medical Manufacturing & Outsourcing - Version A. April 2021 - 5
Medical Manufacturing & Outsourcing - Version A. April 2021 - 6
Medical Manufacturing & Outsourcing - Version A. April 2021 - 7
Medical Manufacturing & Outsourcing - Version A. April 2021 - 8
Medical Manufacturing & Outsourcing - Version A. April 2021 - 9
Medical Manufacturing & Outsourcing - Version A. April 2021 - 10
Medical Manufacturing & Outsourcing - Version A. April 2021 - 11
Medical Manufacturing & Outsourcing - Version A. April 2021 - 12
Medical Manufacturing & Outsourcing - Version A. April 2021 - 13
Medical Manufacturing & Outsourcing - Version A. April 2021 - 14
Medical Manufacturing & Outsourcing - Version A. April 2021 - 15
Medical Manufacturing & Outsourcing - Version A. April 2021 - 16
Medical Manufacturing & Outsourcing - Version A. April 2021 - 17
Medical Manufacturing & Outsourcing - Version A. April 2021 - 18
Medical Manufacturing & Outsourcing - Version A. April 2021 - 19
Medical Manufacturing & Outsourcing - Version A. April 2021 - 20
Medical Manufacturing & Outsourcing - Version A. April 2021 - 21
https://www.nxtbookmedia.com