Medical Design Briefs - June 2021 - 19

system electronics consume 10 mA over 5
seconds (0.00138Hr), then each test
draws 0.0138 mAHr, which supports 250
mAHr/0.0138 mAHr = 18,000 tests be -
fore replacing the battery. However, if the
electrochemical test takes tens of seconds
or even minutes and the electrochemical
reaction requires higher currents, then
much higher capacity batteries must be
employed, which increases the enclosure
volume, weight, and cost. Rechargeable
batteries are an option, but time-sensitive
testing to address immediate treatment
decisions for home use typically avoids
rechargeable batteries.
In such cases, stand-alone potentiostat
modules like the EmStat Pico are ideal
for the analog front-end function. Onchip
sequencers and deep ADC FIFOs
allow the analog front end to operate
while the processor is shut down, thus
saving power. High-speed analog-todigital
conversion enables duty cycling
of the front-end measurement system to
reduce power consumption. In addition
to the battery capacity, it is important to
consider the voltage requirements for
each block. High-precision, wide dynamic
range analog circuits may require
boost circuits and LDOs to ensure clean
stable supply voltages to the measurement
front end.
Conclusion
POC devices to diagnose viruses, joint
infections, or nutrient deficiencies, for
example, are here to stay. They will
become smaller, cheaper, produced in
high volume, and more versatile. As
competition increases, proven measurement
technologies and system design
expertise will be a competitive advantage
and speed time to market. PalmSens, for
example, delivers tested market-ready
potentiostats or calibrated potentiostat
modules to integrate into hardware,
while Tri-Star Design offers turnkey certified
product design and development
services with expertise in high precision,
low-power wireless systems. Both companies
are official partners of Analog
Devices.
References
1. M. Gebala and W. Schuhmann, " Understanding
properties of electrified
interfaces as a prerequisite for label-free
DNA hybridization detection, " Physical
Chemistry Chemical Physics, 2012: Issue 43,
https://doi.org/10.1039/C2CP42382K.
2. H. Zhao et al, " Ultrasensitive supersandwichtype
electrochemical sensor for SARSCoV-2
from the infected COVID-19
patients using a smartphone, " Sensors and
Actuators B: Chemical, " 2021: 327:15,
January 2021, https://doi.org/10.1016/
j.snb.2020. 128899.
3. J. Li and and P. Lillehoj, " Microfluidic
Magneto Immunosensor for Rapid, High
Sensitivity Measurements of SARS-CoV-2
Nucleocapsid Protein in Serum, " ACS
Sensors, 2021: 6, 3, 1270-1278, https://
doi.org/10.1021/acssensors.0c02561.
4. Md. Azahar Ali et al., " Sensing of COVID19
Antibodies in Seconds via Aerosol Jet
Printed Three Dimensional Electrodes, "
medRxiv, September 2020, https://doi.org/
10.1101/2020.09.13.20193722.
5. S. Traynor, " Dynamic Bio Barcode Assay
Enables Electrochemical Detection of a
Cancer Biomarker in Undiluted Human
Plasma: A Sample In Answer Out Approach, "
Angewandte Chemie, 2020: 132, 50,
December 7, 2020, https://doi.org/
10.1002/ange.202009664.
This article was written by Paul Errico
(perrico@tristardes.com), Healthcare Senior
Account Manager, TriStar Design, Hop kinton,
MA, and Ardy van den Berg (info@palmsens.
com), Business Developer, PalmSens, Houten,
The Netherlands. For more information on
TriStar Design, visit http://info.hotims.com/
79414-341. For more information on PalmSens,
visit http://info.hotims.com/79414-370.
Medical Design Briefs, June 2021
Free Info at http://info.hotims.com/79414-795
Cov
ToC
19
https://www.doi.org/10.1016/j.snb.2020 https://www.doi.org/10.1021/acssensors.0c02561 https://www.doi.org/10.1101/2020.09.13.20193722 https://www.doi.org/10.1002/ange.202009664 http://info.hotims.com/79414-341 https://www.doi.org/10.1039/C2CP42382K http://info.hotims.com/79414-370 http://info.hotims.com/79414-795

Medical Design Briefs - June 2021

Table of Contents for the Digital Edition of Medical Design Briefs - June 2021

Medical Design Briefs - June 2021 - Intro
Medical Design Briefs - June 2021 - Cov4
Medical Design Briefs - June 2021 - Cov1a
Medical Design Briefs - June 2021 - Cov1b
Medical Design Briefs - June 2021 - Cov1
Medical Design Briefs - June 2021 - Cov2
Medical Design Briefs - June 2021 - 1
Medical Design Briefs - June 2021 - 2
Medical Design Briefs - June 2021 - 3
Medical Design Briefs - June 2021 - 4
Medical Design Briefs - June 2021 - 5
Medical Design Briefs - June 2021 - 6
Medical Design Briefs - June 2021 - 7
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Medical Design Briefs - June 2021 - Cov3
Medical Design Briefs - June 2021 - CovIV
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