Medical Design Briefs - June 2021 - 21

3D Printed Implants
with Antibiotics
Covering the antibiotics with lamellar
inorganic protectors protects the antibacterial
agents. (Credit: KeAi)
Researchers have fabricated
antibiotic-containing 3D
scaffold implants at high
temperatures. These scaffolds
not only support bone
regeneration but manage
the bone infections that can
arise as a result of injury or surgery. Incorporating antibiotics
into these scaffolds is not straightforward because the 3D printing
process consists of melting the material at high temperatures
and antibiotics are heat sensitive.
Scientists found that covering the antibiotics with lamellar
inorganic protectors, prior to mixing them with the polymer
and placing them in the 3D scaffolds, not only protected the
antibacterial agents but also enabled a more controlled release.
This extended the period the antimicrobials were active and
helped keep local antibiotic concentrations under potentially
toxic levels. At the same time, the cells in contact with these scaffolds
maintained their viability and could perform normal cell
functions, including bone formation - the goal of the implant.
Until now, the direct incorporation of antibiotics and other
bioactive molecules within 3D printed scaffolds has been limited
to the few polymers that can be processed at low temperatures.
This novel approach shows that the library of polymers
can be expanded to include many more.
For more information, visit www.medicaldesignbriefs.com/
roundup/0621/implants.
Bioactive Implant Coatings
Resistant to Most Bacterial
Strains
Multilayer antibacterial
coatings offer a prolonged
effect and a universal
spectrum of
action. (Credit: MISIS)
Multilayer antibacterial coatings
offer a prolonged effect and a universal
spectrum of action. The coating is
based on modified titanium oxide
and several antiseptic components.
The coatings can be used in modern
implantology as a protective layer for
the prevention of concomitant complications
- inflammation or implant rejection.
The multilayer coating synthesizes the protective properties of
nanoparticles, biopolymers, anticoagulants, and antibiotics. The
antibiotic and silver nanoparticles provide an antibacterial effect,
while heparin prevents bacterial cells from sticking to the tissue
surface, which reduces the amount of antibacterial agent required.
The chemical composition of the resulting coating layers was
carefully studied by the developers using infrared and x-ray
photoelectron spectroscopy. Scientists have found out that the
incorporation of therapeutic components occurs throughout
the whole plasma-applied polymer layer.
According to the developers, the coatings can be used as an
antibacterial implant modifier, allowing it to accelerate implantation
by reducing the risks of associated inflammation and
stimulating the growth of osteoblastic cells. Researchers are currently
planning to move to the preclinical development stage.
For more information, visit www.medicaldesignbriefs.com/
roundup/0621/coatings.
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Medical Design Briefs, June 2021
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Medical Design Briefs - June 2021

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