Medical Design Briefs - June 2021 - 30

Surgical Sutures Inspired by Human Tendons
Next-generation sutures
can deliver drugs, prevent
infections, and monitor
wounds.
McGill University
Montreal, QC, Canada
Sutures are used to close wounds and
speed up the natural healing process,
but they can also complicate matters by
causing damage to soft tissues with
their stiff fibers. To remedy the problem,
researchers from Montreal have
developed innovative tough gel
sheathed (TGS) sutures inspired by the
human tendon.
These next-generation sutures contain
a slippery, yet tough gel envelope, imitating
the structure of soft connective tissues.
In putting the TGS sutures to the test, the
researchers found that the nearly frictionless
gel surface mitigated the damage typically
caused by traditional sutures.
Conventional sutures have been around
for centuries and are used to hold wounds
together until the healing process is complete.
But they are far from ideal for tissue
repair. The rough fibers can slice and damage
already fragile tissues, leading to discomfort
and post-surgery complications.
Part of the problem lies in the mismatch
between our soft tissues and the rigid
sutures that rub against contacting tissue,
say the researchers from McGill University
and the INRS Énergie Matériaux Télé -
communications Research Centre.
■ Inspired by the Tendon
To tackle the problem, the team developed
a new technology that mimics the
mechanics of tendons. " Our design is
inspired by the human body, the endo -
tenon sheath, which is both tough and
strong due to its double-network structure.
It binds collagen fibers together while its
elastin network strengthens it, " says lead
author Zhenwei Ma, a PhD student under
the supervision of Assistant Professor
Jianyu Li at McGill University.
The endotenon sheath not only forms a
slippery surface to reduce friction with surrounding
tissues in joints, but it also delivers
necessary materials for tissue repair in
a tendon injury. In the same way, TGS
sutures can be engineered to provide personalized
medicine based on a patient's
needs, say the researchers.
■ Personalized Wound Treatment
" This technology provides a versatile
tool for advanced wound management.
We believe it could be used to deliver
drugs, prevent infections, or even monitor
wounds with near-infrared imaging, " says
Li of the Department of Mechanical
Engineering.
Tough gel sheathed (TGS) sutures. (Credit: Zhenwei Ma, McGill University)
" The ability to monitor wounds locally
and adjust the treatment strategy for better
healing is an exciting direction to
explore, " says Li, who is also a Canada
Research Chair in Biomaterials and
Musculoskeletal Health.
For more information, visit www.mcgill.ca.
Exosome-Coated Stent Heals Vascular Injury, Repairs
Damaged Tissue
The stent delivers
regenerative stem cellderived
therapy to bloodstarved
tissue.
North Carolina State University
Raleigh, NC
Researchers from North Carolina State
University have developed an exosomecoated
stent with a " smart-release " trigger
that could both prevent reopened blood
30
Cov
vessels from narrowing and deliver regenerative
stem cell-derived therapy to
blood-starved, or ischemic, tissue.
Angioplasty - a procedure that
opens blocked arteries - often involves
placing a metal stent to reinforce arterial
walls and prevent them from collapsing
once the blockage is removed.
However, the stent's placement usually
causes some injury to the blood vessel
wall, which stimulates smooth muscle
cells to proliferate and migrate to the
site in an attempt to repair the injury.
www.medicaldesignbriefs.com
ToC
The result is restenosis: a re-narrowing
of the blood vessel previously opened
by angioplasty.
" The inflammatory response that
stents cause can decrease their benefit, "
says Ke Cheng, corresponding author of
the research. " Ideally, if we could stop
smooth muscle cells from over-reacting
and proliferating, but recruit endothelial
cells to cover the stent, it would mitigate the
inflammatory response and prevent reste -
nosis. " Cheng is the Randall B. Terry Jr.
Distinguished Professor in Regenerative
Medical Design Briefs, June 2021
http://www.mcgill.ca http://www.medicaldesignbriefs.com

Medical Design Briefs - June 2021

Table of Contents for the Digital Edition of Medical Design Briefs - June 2021

Medical Design Briefs - June 2021 - Intro
Medical Design Briefs - June 2021 - Cov4
Medical Design Briefs - June 2021 - Cov1a
Medical Design Briefs - June 2021 - Cov1b
Medical Design Briefs - June 2021 - Cov1
Medical Design Briefs - June 2021 - Cov2
Medical Design Briefs - June 2021 - 1
Medical Design Briefs - June 2021 - 2
Medical Design Briefs - June 2021 - 3
Medical Design Briefs - June 2021 - 4
Medical Design Briefs - June 2021 - 5
Medical Design Briefs - June 2021 - 6
Medical Design Briefs - June 2021 - 7
Medical Design Briefs - June 2021 - 8
Medical Design Briefs - June 2021 - 9
Medical Design Briefs - June 2021 - 10
Medical Design Briefs - June 2021 - 11
Medical Design Briefs - June 2021 - 12
Medical Design Briefs - June 2021 - 13
Medical Design Briefs - June 2021 - 14
Medical Design Briefs - June 2021 - 15
Medical Design Briefs - June 2021 - 16
Medical Design Briefs - June 2021 - 17
Medical Design Briefs - June 2021 - 18
Medical Design Briefs - June 2021 - 19
Medical Design Briefs - June 2021 - 20
Medical Design Briefs - June 2021 - 21
Medical Design Briefs - June 2021 - 22
Medical Design Briefs - June 2021 - 23
Medical Design Briefs - June 2021 - 24
Medical Design Briefs - June 2021 - 25
Medical Design Briefs - June 2021 - 26
Medical Design Briefs - June 2021 - 27
Medical Design Briefs - June 2021 - 28
Medical Design Briefs - June 2021 - 29
Medical Design Briefs - June 2021 - 30
Medical Design Briefs - June 2021 - 31
Medical Design Briefs - June 2021 - 32
Medical Design Briefs - June 2021 - 33
Medical Design Briefs - June 2021 - 34
Medical Design Briefs - June 2021 - 35
Medical Design Briefs - June 2021 - 36
Medical Design Briefs - June 2021 - 37
Medical Design Briefs - June 2021 - 38
Medical Design Briefs - June 2021 - 39
Medical Design Briefs - June 2021 - 40
Medical Design Briefs - June 2021 - 41
Medical Design Briefs - June 2021 - 42
Medical Design Briefs - June 2021 - 43
Medical Design Briefs - June 2021 - 44
Medical Design Briefs - June 2021 - 45
Medical Design Briefs - June 2021 - 46
Medical Design Briefs - June 2021 - 47
Medical Design Briefs - June 2021 - 48
Medical Design Briefs - June 2021 - 49
Medical Design Briefs - June 2021 - 50
Medical Design Briefs - June 2021 - 51
Medical Design Briefs - June 2021 - 52
Medical Design Briefs - June 2021 - 53
Medical Design Briefs - June 2021 - 54
Medical Design Briefs - June 2021 - 55
Medical Design Briefs - June 2021 - 56
Medical Design Briefs - June 2021 - 57
Medical Design Briefs - June 2021 - 58
Medical Design Briefs - June 2021 - 59
Medical Design Briefs - June 2021 - 60
Medical Design Briefs - June 2021 - 61
Medical Design Briefs - June 2021 - 62
Medical Design Briefs - June 2021 - 63
Medical Design Briefs - June 2021 - 64
Medical Design Briefs - June 2021 - 65
Medical Design Briefs - June 2021 - 66
Medical Design Briefs - June 2021 - 67
Medical Design Briefs - June 2021 - 68
Medical Design Briefs - June 2021 - 69
Medical Design Briefs - June 2021 - 70
Medical Design Briefs - June 2021 - 71
Medical Design Briefs - June 2021 - 72
Medical Design Briefs - June 2021 - 73
Medical Design Briefs - June 2021 - 74
Medical Design Briefs - June 2021 - 75
Medical Design Briefs - June 2021 - 76
Medical Design Briefs - June 2021 - 77
Medical Design Briefs - June 2021 - 78
Medical Design Briefs - June 2021 - 79
Medical Design Briefs - June 2021 - 80
Medical Design Briefs - June 2021 - 81
Medical Design Briefs - June 2021 - 82
Medical Design Briefs - June 2021 - 83
Medical Design Briefs - June 2021 - 84
Medical Design Briefs - June 2021 - 85
Medical Design Briefs - June 2021 - 86
Medical Design Briefs - June 2021 - 87
Medical Design Briefs - June 2021 - 88
Medical Design Briefs - June 2021 - 89
Medical Design Briefs - June 2021 - 90
Medical Design Briefs - June 2021 - 91
Medical Design Briefs - June 2021 - 92
Medical Design Briefs - June 2021 - 93
Medical Design Briefs - June 2021 - 94
Medical Design Briefs - June 2021 - 95
Medical Design Briefs - June 2021 - 96
Medical Design Briefs - June 2021 - 97
Medical Design Briefs - June 2021 - 98
Medical Design Briefs - June 2021 - 99
Medical Design Briefs - June 2021 - 100
Medical Design Briefs - June 2021 - Cov3
Medical Design Briefs - June 2021 - CovIV
https://www.nxtbook.com/smg/techbriefs/21MDB10
https://www.nxtbook.com/smg/techbriefs/21MDB09
https://www.nxtbook.com/smg/techbriefs/21MDB08
https://www.nxtbook.com/smg/techbriefs/21MDB07
https://www.nxtbook.com/smg/techbriefs/21MDB06
https://www.nxtbook.com/smg/techbriefs/21MDB05
https://www.nxtbook.com/smg/techbriefs/21MDB04
https://www.nxtbook.com/smg/techbriefs/21MDB02
https://www.nxtbookmedia.com