Medical Design Briefs - July 2021 - 29

and training hub located at St Vincent's
Hospital Melbourne.
Co-author and associate professor
Claudia Di Bella, an orthopedic surgeon
at St. Vincent's Hospital Melbourne, says
the study showcases the possibilities that
open up when clinicians, engineers and
biomedical scientists come together to
address a clinical problem.
" A common problem faced by clinicians
is the inability to access technological
experimental solutions for the problems
they face daily, " Di Bella says.
" While a clinician is the best professional
to recognize a problem and think
about potential solutions, biomedical
engineers can turn that idea into reality.
" Learning how to speak a common language
across engineering and medicine
is often an initial barrier, but once this is
overcome, the possibilities are endless. "
Di Bella says clinicians, like surgeons,
are used to applying their manual skills,
as well as technical tools, to " fix " a problem
within the body.
" Bioengineering technologies can significantly
increase the armory of options
available to clinicians and offer the possibility
to address problems never solved
before, as well as to give personalized,
patient-specific, solutions.
" This is an incredible step forward in
medicine and one that excites patients
and clinicians alike. "
■ Future Treatment Toolkit
Currently there are few treatment
options for people who lose a significant
amount of bone or tissue due to illness or
injury, making it common to use amputation
or metal implants. While a few clinical
trials of tissue engineering have been
conducted around the world, key bioengineering
challenges still need to be
addressed for 3D bioprinting technology
to become a standard part of a surgeon's
toolkit. In orthopedics, a major sticking
point is the development of a bioscaffold
that works across both bone and cartilage.
" Our new method is so precise we're
creating specialized bone and cartilagegrowing
microstructures in a single
bioscaffold, " O'Connell says.
" It's the surgical ideal - one integrated
scaffold that can support both types of cells,
to better replicate the way the body works. "
Tests with human cells have shown
bioscaffolds built using the new method
are safe and nontoxic. The next steps for
the researchers will be testing designs to
optimize cell regeneration and investigating
the impact on cell regrowth of
different combinations of biocompatible
materials.
■ Step-by-Step: How to Reverse
Print a Bioscaffold
The new method - which re -
searchers have dubbed Negative
Embodied Sacrificial Template 3D
(NEST3D) printing - uses simple PVA
glue as the basis for the 3D printed
mold. Once the biocompatible material
injected into the mold has set, the entire
structure is placed in water to dissolve
the glue, leaving just the cell-nurturing
bioscaffold.
Study first author, PhD researcher
Stephanie
Doyle,
says
the method
enabled researchers to rapidly test combinations
of materials to identify those
most effective for cell growth.
" The advantage of our advanced injection
molding technique is its versatility, "
Doyle says.
" We can produce dozens of trial
bioscaffolds in a range of materials -
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Medical Design Briefs - July 2021

Table of Contents for the Digital Edition of Medical Design Briefs - July 2021

Medical Design Briefs - July 2021 - Intro
Medical Design Briefs - July 2021 - Cov4
Medical Design Briefs - July 2021 - Cov1
Medical Design Briefs - July 2021 - Cov2
Medical Design Briefs - July 2021 - 1
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Medical Design Briefs - July 2021 - Cov3
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