Medical Design Briefs - December 2021 - 23

What if the Life of Plastic
Gears Could be Calculated?
Wearable Head Scanner
Allows Mobility During
Brain Scans
Brain scans that take place in
confined spaces could eventually
be a thing of the past. (Credit:
iStock/@JohnnyGreig)
Researchers have proposed a
solution to both clearly visualize
and accurately assess the brain
via photoacoustic imaging with a
stretchable, flexible material.
The researchers plan to build a
prototype of a wearable scanner
to advance the diagnosis and
treatment of neurological issues through accessible testing.
Photoacoustic imaging sends near-infrared laser pulses into
the brain, generating harmless heat that converts to ultrasonic
waves. The proposed wearable scanner wraps a sensor securely
around the head, increasing the surface area contact and delivering
an acoustic signal strong enough to penetrate the skull.
The researchers will integrate a photoacoustic imaging scanner
into a stretchable, flexible head covering. The resulting
device will be able to visualize the cerebral cortex of the brain,
which facilitates perception, awareness, memory, language,
consciousness and more, and deliver real-time imaging while a
person performs tasks or answers questions.
The new technology could be used to detect brain injuries or
developmental disorders in both children and adult patients, Jing
said, in discussing some of the possible applications. And future
iterations of the device may be applied to other areas of the body,
such as the chest, to detect breast cancer.
For more information, visit www.medicaldesignbriefs.com/
roundup/1221/scanner.
The biosensor detects the
presence of cancer through
a blood test. (Credit:
Universitat Politècnica de
València)
Biosensor Aids in Early
Diagnosis of Breast Cancer
A prototype of a new biosensor
helps detect breast cancer in its earliest
stages. The development of this
biosensor falls within the field known
as liquid biopsy, which helps detect the
presence of cancer through a blood
test. The mesoporous biosensor is
easy to use, low cost, and provides
results
in
a
very
short
time -
between 30 and 60 minutes - from a
sample of the patient's plasma.
The biosensor is composed of a
nanomaterial - a nanoporous alumina
- that facilitates the detection in plasma of miR-99a-5p
microRNA, which is associated with breast cancer. Until now,
this has been done by using complex and time-consuming
techniques, which means that this system could not be used as
a diagnostic tool in the clinical setting.
The nanopores of the biosensor are loaded with a dye -
rhodamine B - and sealed with an oligonucleotide. When
interacting with the plasma sample, if the pore gates do not
detect the presence of the microRNA, they remain closed; in
contrast, in the presence of miR-99a-5p, the pore gates open
and the dye is released.
For more information, visit www.medicaldesignbriefs.com/
roundup/1221/biosensor.
Medical Design Briefs, December 2021
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http://info.hotims.com/79420-761 http://www.medicaldesignbriefs.com/roundup/1221/scanner http://info.hotims.com/79420-762 http://www.medicaldesignbriefs.com/roundup/1221/biosensor
Medical Design Briefs - December 2021

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