Medical Design Briefs - November 2022 - 33

become entangled with each other, they
create a molecular network that demonstrates
unprecedented toughness and
resilience for hydrogel materials - on
par with the body's natural cartilage.
When combined with an adhesive layer
containing positively charged polymer
molecules (chitosan), the resulting hybrid
material is able to bind to tissues
stronger than any other available adhesive,
stretch up to 20 times its initial
length, and attach to wet tissue surfaces
undergoing dynamic movement (e.g., a
beating heart).
Studies of the hydrogel adhesive
demonstrated that it is capable of withstanding
three times the amount of tension
that disrupts the best current medical
adhesives, maintaining its stability
and adhesion when implanted into rats
for two weeks, and sealing a hole in a pig
heart that was subjected to tens of thousands
of cycles of pumping. Additionally,
it caused no tissue damage or adhesions
to surrounding tissues when applied to a
liver hemorrhage in mice.
The hydrogel adhesive has numerous
potential applications in the medical
field, either as a patch that can be cut to
desired sizes and applied to many tissues
including bone, cartilage, tendon, or
pleura, or as an injectable solution for
deeper injuries. It can also be used to attach
medical devices to their target structures,
such as an actuator to support
heart function. While the current iteration
is designed to be a permanent structure,
it could be made to biodegrade
over time as the body heals from injury.
A newer version of the adhesive has
thermoreactive properties that cause it
to contract when heated to body temperature,
helping to dynamically close
wounds and prevent bacterial growth
during healing.
For more information, visit https://
wyss.harvard.edu. For information on licensing
the technology, contact: wyss_bd@
wyss.harvard.edu.
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A new, flexible adhesive material inspired by the
glue secreted by slugs adheres to biological tissues
(even when wet) without causing toxicity
and can be formed into either sheets (teal blue)
or custom shapes (dark blue). (Credit: Wyss Institute
at Harvard University)
Medical Design Briefs, November 2022
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33
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Medical Design Briefs - November 2022

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