Medical Design Briefs - December 2022 - 20

n Mouthguard
Controls Devices
by Biting
A novel bite-controlled optoelectronic system is capable
of translating complex bite patterns into data
inputs. (Credit: National University of Singapore)
Individuals who have
limited hand function
can control devices such
as smartphones, computers,
and wheelchairs by
wearing a smart mouthguard.
The novel bitecontrolled
optoelectronic
system con tains integrated pressure sensors to detect occlusal
patterns. These patterns are translated into data inputs with 98
percent accuracy.
The research team first designed a sensor comprising a
series of contact pads containing different colored phosphors,
which emit light in response to pressure. The array of
contact pads is placed within a flexible mouthguard.
Biting causes the contact pads to mechanically deform
and emit light in different colors and intensities, which
can be measured and processed using machine learning
algorithms. The data collected can be used for highly accuracy
remote control and operation of various electronic
devices.
For more information, visit www.medicaldesignbriefs.com/
roundup/1222/mouthguard.
n Gel-Like, Radioactive
Implant Kills Pancreatic
Cancer
Researchers have developed a twopronged
approach to treating pancreatic
cancer that has produced the best
results ever seen in mouse trials. (Credit:
Duke University)
Biomedical engineers have
demonstrated the most effective
treatment for pancreatic
cancer ever recorded
in mouse models. The
new treatment completely
eliminated
tumors
in
80
percent of mice across several
model types, including
those considered the most difficult to treat.
The approach combines traditional chemotherapy drugs
with a new method for irradiating the tumor. Rather than
delivering radiation from an external beam that travels
through healthy tissue, the treatment implants radioactive
iodine-131 directly into the tumor within a gel-like depot
that protects healthy tissue and is absorbed by the body after
the radiation fades away.
The researchers used a substance made of elastin-like
polypeptides (ELPs), which are synthetic chains of amino
acids bonded together to form a gel-like substance with tailored
properties. The ELP depot encases the iodine-131 and
prevents it from leaking out into the body. The iodine-131
emits beta radiation, which penetrates the biogel and deposits
almost all its energy into the tumor without reaching the
surrounding tissue. Over time, the ELP depot degrades into
its constituent amino acids and is absorbed by the body.
For more information, visit www.medicaldesignbriefs.com/
roundup/1222/implant.
20
A new sensor will be useful in micro phones that
facilitate communication in disaster situations
and for healthcare devices. (Credit: POSTECH)
A 3D printed light-sensing medical device
could help millions of people worldwide with
lupus. (Credit: McAlpine Group, University of
Minnesota)
n Light-Sensing
Device for Lupus
A 3D printed lightsensing
medical device is
placed directly on the skin
and gives real-time feedback
to correlate light exposure
with disease flareups.
The device could
help millions of people
worldwide with lupus and
other light- sensitive diseases by providing access to more personalized
treatments and information to determine what causes
their symptoms.
The 3D printed device with a flexible UV-visible light detector
can be placed on the skin. The device is integrated
with a custom-built portable console to continuously monitor
and correlate light exposure to symptoms.
The device consists of multiple layers of materials printed
on a biocompatible silicone base. The layers include electrodes
and optical filters. Filters could be changed out depending
on the wavelength of light that needs to be assessed.
The research team also used zinc oxide to collect the ultraviolet
(UV) light and convert it to electrical signals. The device
is mounted on the skin and a custom-built console is
attached to capture and store the data.
For more information, visit www.medicaldesignbriefs.com/
roundup/1222/lupus.
n Skin-Attachable
Auditory Sensor
Functions in Noisy
Environments
A new auditory sensor
will be useful for healthcare
devices that diagnose
respiratory diseases.
The skin-attachable
device will also be useful
as a sensor in microphones
to aid in facilitating
communication
in disaster situations. It
can clearly detect voices even in harsh noisy environments.
The team applied polymer electrets to microelectromechanical
systems (MEMS) to develop an auditory sensor. The
electret-powered and hole-patterned polymer diaphragm is
incorporated into a skin-attachable auditory sensor, which reduces
the need for a battery. The diaphragm structure based
on MEMS technology gives the auditory sensor high wearability
and portability.
The diaphragm enables the sensor to detect the neckskin
vibration generated when a person speaks. Those using
this sensor can clearly hear sounds even in noisy places,
or when their faces are completely covered with a gas
mask.
For more information, visit www.medicaldesignbriefs.com/
roundup/1222/sensor.
www.medicaldesignbriefs.com
Medical Design Briefs, December 2022
http://www.medicaldesignbriefs.com/roundup/1222/mouthguard http://www.medicaldesignbriefs.com/roundup/1222/lupus http://www.medicaldesignbriefs.com/roundup/1222/sensor http://www.medicaldesignbriefs.com/roundup/1222//implant http://www.medicaldesignbriefs.com

Medical Design Briefs - December 2022

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Medical Design Briefs - December 2022 - COV1A
Medical Design Briefs - December 2022 - COV1B
Medical Design Briefs - December 2022 - Cov1
Medical Design Briefs - December 2022 - Cov2
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Medical Design Briefs - December 2022 - Cov4
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