Medical Design Briefs - December 2022 - 22

Polyolefin Primer/Adhesive
X21Med passes ISO 10993-5 test
for non-cytotoxicity
n Device Diagnoses Eye
Disorders
Cellularis detects degenerative
ophthalmic diseases. (Credit:
Laboratory of Applied Photonics
Devices)
* One component system
*
*
*
Researchers have developed an
ophthalmological device that can
be used to diagnose some degenerative
eye disorders long before the
onset of the first symptoms. In early
clinical trials, the prototype was
shown to produce images with a
sufficient degree of precision in
just five seconds.
The retinal camera features two
oblique beams, trained on the white
of the eye, coupled with an adaptive
Low viscosity of <250 cps
Cures tough, not rigid
Room temperature cures
+1.201.343.8983 * main@masterbond.com
www.masterbond.com
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22
optical system that corrects distortions in the light waves to
produce a clear image. This technology, dubbed transscleral
optical imaging, is similar to existing retinal imaging systems in
its use of infrared light beams. But it has one key difference:
The beams focus obliquely through the white of the eye,
which circumvents the problem of excess light caused by the
highly reflective cone photoreceptor cells, located in the center
of the eye, when the retina is illuminated via the pupil.
The light waves are then captured by the camera as they
exit the eye through the pupil. The team says they had something
of a eureka moment when they saw the first clear image
on screen, since it was the first time anyone had observed
this part of the human body using a clinically compatible
imaging camera.
For more information, visit www.medicaldesignbriefs.com/
roundup/1222/eye-disorders.
n AI: Microneedle Patches
Restore Hair
Researchers have used artificial
intelligence (AI) to predict comHair
regrew thicker in mice treated
with an MnMNP (righ t). (Credit:
Adapted from Nano Letters
2022, DOI: 10.1021/acs.nanolett.
2c03119)
pounds that could neutralize
baldness- causing reactive oxygen
species in the scalp. They constructed
a proof-of-concept microneedle
patch and effectively regenerated
hair on mice.
The team chose transitionmetal
thiophosphate compounds as potential nanozyme candidates.
They tested machine-learning models with 91 different
transition-metal, phosphate, and sulfate combinations,
and the techniques predicted that MnPS3 would have the
most powerful SOD-like ability.
Next, MnPS3 nanosheets were synthesized through chemical
vapor transport of manganese, red phosphorus, and sulfur
powders. In initial tests with human skin fibroblast cells, the
nanosheets significantly reduced the levels of reactive oxygen
species without causing harm.
Based on these results, the team prepared MnPS3 microneedle
patches and treated androgenic alopecia-affected mouse
models with them. Within 13 days, the animals regenerated
thicker hair strands that more densely covered their previously
bald backsides than mice treated with testosterone or minoxidil.
For more information, visit www.medicaldesignbriefs.com/
roundup/1222/hair.
www.medicaldesignbriefs.com
Medical Design Briefs, December 2022
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Medical Design Briefs - December 2022

Table of Contents for the Digital Edition of Medical Design Briefs - December 2022

Medical Design Briefs - December 2022 - COV1A
Medical Design Briefs - December 2022 - COV1B
Medical Design Briefs - December 2022 - Cov1
Medical Design Briefs - December 2022 - Cov2
Medical Design Briefs - December 2022 - 1
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Medical Design Briefs - December 2022 - Cov3
Medical Design Briefs - December 2022 - Cov4
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https://www.nxtbook.com/smg/techbriefs/23MDB12
https://www.nxtbook.com/smg/techbriefs/23MDB11
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https://www.nxtbook.com/smg/techbriefs/22MDB12
https://www.nxtbook.com/smg/techbriefs/22MDB11
https://www.nxtbook.com/smg/techbriefs/22MDB10
https://www.nxtbook.com/smg/techbriefs/22MDB09
https://www.nxtbook.com/smg/techbriefs/22MDB08
https://www.nxtbook.com/smg/techbriefs/22MDB07
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https://www.nxtbook.com/smg/techbriefs/techleaders21
https://www.nxtbook.com/smg/techbriefs/22MDB03
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https://www.nxtbook.com/smg/techbriefs/21MDB12
https://www.nxtbook.com/smg/techbriefs/21MDB11
https://www.nxtbook.com/smg/techbriefs/21MDB10
https://www.nxtbook.com/smg/techbriefs/21MDB09
https://www.nxtbook.com/smg/techbriefs/21MDB08
https://www.nxtbook.com/smg/techbriefs/21MDB07
https://www.nxtbook.com/smg/techbriefs/21MDB06
https://www.nxtbook.com/smg/techbriefs/21MDB05
https://www.nxtbook.com/smg/techbriefs/21MDB04
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