Medical Design Briefs - December 2022 - 28

us to get really good measurements of
their gait speed. And with so much data,
we were able to perform aggregation
that allowed us to see very small differences, "
Zhang says.
n Better, Faster Results
Drilling down on these variabilities offered
some key insights. For instance,
the researchers showed that daily fluctuations
in a patient's walking speed correspond
with how they are responding to
their medication - walking speed may
improve after a dose and then begin to
decline after a few hours, as the medication
impact wears off.
" This enables us to objectively measure
how your mobility responds to your medication.
Previously, this was very cumbersome
to do because this medication effect
could only be measured by having the patient
keep a journal, " Liu says.
A clinician could use these data to adjust
medication dosage more effectively and
accurately. This is especially important
since drugs used to treat disease symptoms
can cause serious side effects if the patient
receives too much.
strate
The researchers were able to demonstatistically
significant
garding
Parkinson's progression after
results restudying
50 people for just one year. By
contrast, an often-cited study by the Michael
J. Fox Foundation involved more
than 500 individuals and monitored them
for more than five years, Katabi says.
" For a pharmaceutical company or a
biotech company trying to develop medicines
for this disease, this could greatly
reduce the burden and cost and speed
up the development of new therapies, "
she adds.
Katabi credits much of the study's success
to the dedicated team of scientists
and clinicians who worked together to
tackle the many difficulties that arose
along the way. For one, they began the
study before the COVID-19 pandemic,
so team members initially visited people's
homes to set up the devices. When
that was no longer possible, they developed
a user-friendly phone app to remotely
help participants as they deployed
the device at home.
Through the course of the study, they
learned to automate processes and reduce
effort, especially for the participants and
clinical team.
This knowledge will prove useful as
they look to deploy devices in at-home
studies of other neurological disorders,
such as Alzheimer's, ALS, and Huntington's.
They also want to explore how
these methods could be used in conjunction
with other work from the Katabi lab
showing that Parkinson's can be diagnosed
by monitoring breathing, to collect
a holistic set of markers that could
diagnose the disease early and then be
used to track and treat it.
" This radio-wave sensor can enable
more care (and research) to migrate from
hospitals to the home where it is most desired
and needed, " says Ray Dorsey, a professor
of neurology at the University of
Rochester Medical Center, co-author of
Ending Parkinson's, and a co-author of this
research paper. " Its potential is just beginning
to be seen. We are moving toward a
day where we can diagnose and predict
disease at home. In the future, we may
even be able to predict and ideally prevent
events like falls and heart attacks. "
This work is supported, in part, by the
National Institutes of Health and the Michael
J. Fox Foundation.
This article was written by Adam
Zewe, MIT. For more information, visit
https://news.mit.edu. A video of the
technology is available at https://www.
youtube.com/watch?time_continue=9&v=8lFzABIEGBE&feature=emb_
logo&themeRefresh=1.
Endoscope
Uses Bendable GRIN Lens for 3D Microscopy
Needle-like flexible imaging
endoscope could improve
biopsies and cancer
treatment.
Optica
Washington, DC
Researchers have created a flexible
needle- like endoscopic imaging probe
that can acquire 3D microscopic images of
tissue. The bendability is possible thanks
to a new flexible graded index (GRIN)
lens developed by the researchers.
GRIN lenses, originally developed for
the telecommunications industry, are
commonly used to perform fluorescence
microscopy approaches that can image
deep into tissues. However, the fact that
they are rigid components has limited
their use clinically.
" When a traditional biopsy is performed,
it represents a single moment in time and
28
Researchers have created a long and flexible GRIN lens (pictured). The lens was used to create a
bendable endoscopic imaging probe that can acquire 3D microscopic images. (Credit: Guigen Liu,
Harvard Medical School and Brigham and Women's Hospital)
can take days to get results back from the
laboratory, " says research lead Guigen Liu
from Harvard Medical School. " Our bendable
imaging probes could shorten the
waiting time to minutes and enable new
www.medicaldesignbriefs.com
approaches that use imaging to dynamically
monitor tissue changes, for instance, how
tumors react to treatments over time. "
In the Optica Publishing Group journal
Optics Express, the researchers deMedical
Design Briefs, December 2022
https://news.mit.edu https://youtube.com/watch?time_continue=9&v=8lFzABIEGBE&feature=emb_logo&themeRefresh=1 http://www.medicaldesignbriefs.com

Medical Design Briefs - December 2022

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Medical Design Briefs - December 2022 - COV1A
Medical Design Briefs - December 2022 - COV1B
Medical Design Briefs - December 2022 - Cov1
Medical Design Briefs - December 2022 - Cov2
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