Medical Design Briefs - January 2023 - 33

delivery, and gene editing. So far, tissue
nanotransfection has also been achieved
in blood vessel and nerve tissue. In addition,
recent work has shown that topical
tissue nanotransfection can achieve cellspecific
gene editing of skin wound tissue
to improve wound closure.
Other study authors include Andrew
Clark, Subhadip Ghatak, Poornachander
Reddy Guda, Mohamed S. El Masry, and Yi
Xuan, all of IU, and Amy Y. Sato and Teresita
Bellido of Purdue University.
This work was supported by Department
of Defense Discovery Award W81XWH-20-1-251.
It is also supported in part by
NIH grant DK128845 and Lilly Endowment
INCITE (Indiana Collaborative Initiative
for Talent Enrichment).
For more information, visit https://
news.iu.edu. Contact: Chandan Sen, PhD,
cksen@iu.edu.
An Investigation to Test Remote-Controlled Drug-Delivery
Implant Launched on SpaceX CRS-26
The remotely controlled drug-delivery
implant could one day provide extended,
adjustable medication for patients.
ISS National Laboratory
Melbourne, FL
A new remotely controlled drug-delivery implant could one
day provide extended, adjustable medication for patients who
need daily medicine but lack medical access - even those on
spacecraft headed for Mars. Houston Methodist Research Institute
researchers have developed such an implant. They are leveraging
the International Space Station (ISS) National Laboratory
to test the implant's ability to be controlled in space
from a device on Earth.
The investigation, launching on SpaceX's 26th Commercial
Resupply Services mission (SpaceX CRS-26), will lay the
groundwork for future experiments from the research team
involving rodent models on the ISS. The goal is to improve
the implant's ability to transmit signals to Earth and ensure
the drug-delivery system is safe for humans, says Alessandro
Grattoni, professor of nanomedicine at Houston Methodist
Research Institute.
" We're preparing for the first demonstration of a remotely
controlled telemedicine implant in an animal model on the
ISS. It's the ultimate sci-fi medicine in space, " Grattoni says.
" And beyond our investigations, the implant could provide a
valuable technology for drug dosing in rodent research studies
with no need for astronaut time. "
The implant uses nanofluidics technology that combines
membranes with very small nanochannels to deliver a controlled
drug dose through diffusion. This investigation builds upon the
research team's previous ISS National Lab-sponsored experiments
that studied fluid flow through nanochannels to design
the implant's ability to release specific amounts of drugs for individualized
treatment. Grattoni also led an investigation that tested
the implantable nanochannel drug-delivery system in a roExtend
The Life of Tools and
Wear Surfaces Up to 1000%.
Improve and renew Micro-Electronic Tools, Surgical Instruments and MicroLaboratory
Instruments with the Hunter Carbitron 300. This simple easy-touse
process applies tungsten-carbide to tools and wear surfaces extending
the life up to 1000%.
The Carbitron 300 system, consisting of an adjustable power supply and
vibrating hand-tool is a heavy-duty unit incorporating the features of units
selling for 5 - 10 times its low price.
Used for Tissue Forceps, Needle Holders, Micro Needle Holders, Micro Pliers etc.
Hunter Products, Inc.
908-526-8440
www.hunterproducts.com
E-mail: hunter@hunterproducts.com
The investigation launches on SpaceX's 26th Commercial Resupply Services
mission (SpaceX CRS-26). (Credit: SpaceX)
Medical Design Briefs, January 2023
www.medicaldesignbriefs.com
33
https://news.iu.edu http://info.hotims.com/84475-755 http://www.medicaldesignbriefs.com
Medical Design Briefs - January 2023

Table of Contents for the Digital Edition of Medical Design Briefs - January 2023
