Medical Design Briefs - April 2023 - 19

A biosensing device produced in such a
way would enable both the monitoring
and
regulation of physiological processes
and the development of new analytical
tools. (Credit: ACS Synth. Biol.)
n Biosensor: New Drugs,
Sensory Organs on a Chip
A synthetic biosensor that
mimics properties found in
cell membranes and provides
an electronic readout
of activity could lead to a better
understanding of cell biology,
development of new
drugs, and the creation of
sensory organs on a chip capable
of detecting chemicals,
similar to how noses and tongues work.
The biosensor uses synthetic biology to re-create a cell membrane
and its embedded proteins, which are gatekeepers of
cellular functions. A conducting sensing platform allows for an
electronic readout when a protein is activated. Being able to
test if and how a molecule reacts with proteins in a cell membrane
could generate a great many applications.
It starts with a conducting polymer, which is soft and easy to
work with, on top of a support that together act as an electric
circuit that is monitored by a computer. A layer of lipid (fat)
molecules, which forms the membrane, lies on top of the polymer,
and the proteins of interest are placed within the lipids.
For more information, visit www.medicaldesignbriefs.com/
roundup/0423/biosensor.
n 'Shape-Shifting'
Implanted Device to
Provide Continuous
BP Monitoring
SMARTSHAPE
Dr. Atif Shazid, University
ham;
of
Professor William Wijns,
BirmingUniversity
of Galway; Prof. Ciarán Ó
hÓgartaigh, president of University of
Galway; and Dr. Sandra Ganly, senior research
fellow at University of Galway.
(Credit: University of Galway)
consortium,
led from University of
Galway, will develop an implantable
medical device
for continuous blood pressure
monitoring. The consortium
has developed an
IP-protected technologically
disruptive sensor for continuous
pressure measurement.
They plan to address challenges related to bio compatibility,
longevity, and delivery to the target tissue. These need to be
overcome to deliver the sensor to the market.
This project will address these challenges by formulating
an innovative biomaterial: a novel temperature-dependent
shape memory polymer (SMP). SMPs will enable the development
of a microsensor that can be curled up, introduced into
the body through a minimally invasive procedure, and
opened up when placed at body temperature to take a predefined
shape.
For more information, visit www.medicaldesignbriefs.com/
roundup/0423/shape-shifting.
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Medical Design Briefs, April 2023
www.medicaldesignbriefs.com
19
http://www.medicaldesignbriefs.com/roundup/0423/biosensor http://www.medicaldesignbriefs.com/roundup/0423/shape-shifting http://info.hotims.com/84478-741 http://www.medicaldesignbriefs.com
Medical Design Briefs - April 2023

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